PMID: 7370954Apr 15, 1980Paper

Serum immunoglobulin levels in childhood Hodgkin's disease. Effect of splenectomy and long-term follow-up

Cancer
P D WalzerC Tan

Abstract

Children with Hodgkin's disease had significantly elevated serum IgG and IgA levels but normal IgM and IgD levels when compared with healthy age- and sex-matched controls. The increased serum IgG and IgA levels occurred in all four clinical stages of Hodgkin's disease but were not related to histologic cell type. Following staging splenectomy, serum IgG, IgA, and IgD levels fell by 20% in patients who recieved radiation therapy then returned to preoperative levels; by contrast, serum IgM levels fell by 50% and remained there for at least 36 months. Patients who received chemotherapy had a persistent decline in serum levels of all immunoglobulin classes by at least 40%. Thus, staging splenectomy per se appears to be at least partly responsible for the postoperative decline in serum IgM levels and this effect is enchanced by aggressive treatment of the Hodgkin's disease.

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Citations

Apr 3, 2001·Molecular Immunology·J L Preud'hommeE Lelièvre
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·D R Howard
Jan 1, 1983·Cancer Investigation·F Rosner, M H Zarrabi
Jan 1, 1981·Journal of Surgical Oncology·W H Cole

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