PMID: 9169091Apr 1, 1997Paper

Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery

Biochemical and Molecular Medicine
F F CasanuevaJ F Caro

Abstract

Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Serum leptin concentrations increase in correlation with the percentage of body fat, but besides that little is known about the physiological actions of leptin in humans. In order to understand the role of leptin in severe malnutrition, in the present work 10 patients recently diagnosed with anorexia nervosa were studied both before and 2 months later, after partial weight recovery, and were compared with 18 normal-weight women as controls. Leptin was measured by a newly developed radioimmunoassay and both IGF-I and IGFBP-3 were measured by commercial radioimmunoassays. The mean (+/-SE) serum leptin concentrations (in microgram/liter) were 18.1 +/- 2.0 in control women with BMI of 21.1 +/- 0.3, significantly higher (P < 0.01) than that in the anorexia nervosa patients at diagnosis (2.2 +/- 0.1, BMI 15.3 +/- 0.6). These differences were also observed in IGF-I values (microgram/liter) that were 228.0 +/- 14.6 in controls and 157.4 +/- 28.7 in anorexia nervosa patients (P < 0.02). No differences were observed in IGF-BP3. After treatment, patients with anorexia nervosa experienced an increase in BMI (17.1 +/- 0.5, P < 0.0001 vs before) alth...Continue Reading

References

Jan 1, 1987·Journal of Steroid Biochemistry·F F CasanuevaJ Devesa
Sep 1, 1995·Nature Medicine·F LönnqvistM Schalling
Jul 28, 1995·Science·M A PelleymounterF Collins
Jun 1, 1995·The Journal of Clinical Investigation·R V ConsidineJ F Caro
Feb 1, 1996·The New England Journal of Medicine·F Rohner-Jeanrenaud, B Jeanrenaud

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Citations

May 8, 2009·European Journal of Nutrition·Julia EnglChristoph F Ebenbichler
Jul 5, 2003·Journal of Psychiatric Research·K HoltkampB Herpertz-Dahlmann
Nov 5, 2003·Frontiers in Neuroendocrinology·Massimo ScacchiFrancesco Cavagnini
Aug 12, 2000·Psychoneuroendocrinology·T D BrewertonW T Garvey
Feb 6, 2002·Nutrition·Ana Cristina PalacioFernando Monckeberg
Apr 9, 2013·Psychological Medicine·G KohlboeckUNKNOWN LISA-plus stuStudy Group
Jul 9, 1999·Clinical Endocrinology·A VarvarigouN G Beratis
Aug 16, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sarah E Gairdner, Catherine E Amara
Dec 3, 2011·International Journal of Medical Sciences·Tasneem Fatema Hasan, Hunaid Hasan
Nov 5, 1998·Journal of Endocrinological Investigation·R PeinòC Dieguez
Feb 23, 2011·Regulatory Peptides·Małgorzata Janas-KozikJanusz K Rybakowski
Mar 24, 2007·Metabolism: Clinical and Experimental·Ivana DostalovaJara Nedvidkova
Mar 18, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiaki ShimizuYuichiro Yamashiro
Nov 24, 1999·Frontiers in Neuroendocrinology·F F Casanueva, C Dieguez
Apr 29, 2015·The American Journal of Medicine·Jessica L LeeThomas E Finucane
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·J López-SorianoJ M Argilés
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Oct 10, 2002·European Journal of Clinical Nutrition·A C FreemanM Pai
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Virginie TolleBruno Estour
Jul 14, 1998·The Journal of Clinical Endocrinology and Metabolism·A Leal-CerroF F Casanueva
May 2, 1998·Nutrition Reviews·J M Friedman
Apr 9, 2005·The American Journal of Clinical Nutrition·Verena HaasManfred J Müller
Mar 29, 2002·The Journal of Laboratory and Clinical Medicine·Robert FrederichClaire Pomeroy
Dec 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johanna Louise KeelerHubertus Himmerich

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