PMID: 8611606Jan 12, 1996Paper

Serum independent liposome uptake by mouse liver

Biochimica Et Biophysica Acta
F Liu, D Liu

Abstract

The rate of liposome clearance from blood by the reticuloendothelial system (RES), primarily the Kupffer cells of the liver, depends largely on liposome composition. Inclusion of phosphatidylserine or dicetyl phosphate into liposomes with a simple composition of phosphatidylcholine and cholesterol increases liposome clearance, while inclusion of GM1 or amphipathic poly(ethylene glycol) decreases the rate of liposome clearance. To understand the underlying mechanism by which liposome clearance is regulated by the RES, we have developed a simple liver perfusion system. Using mouse liver as a model, we demonstrated that hepatic uptake of neutral or negatively charged liposomes does not involve serum components. Liver uptake of liposomes is directly related to the surface characteristics of liposomes. Liposomes with a neutral composition of phosphatidylcholine and cholesterol exhibit relatively low liver uptake. Inclusion of PS or DCP into these liposome dramatically enhances liposome uptake by the perfused liver. Conversely, inclusion of GM1 or PEG derivatives into liposomes greatly reduces the liposome uptake by the mouse liver. In contrast to the neutral or negatively charged liposomes, serum enhances the liver uptake of positiv...Continue Reading

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·K J WilliamsW V Rodrigueza
Jun 6, 2000·Advanced Drug Delivery Reviews·H KiwadaH Harashima
Sep 23, 2000·International Journal of Pharmaceutics·T IshidaH Kiwada
Jun 14, 2002·International Journal of Pharmaceutics·Tatiana S LevchenkoVladimir P Torchilin
Jul 9, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Scott R BurksJoseph P Y Kao
May 19, 2000·Antimicrobial Agents and Chemotherapy·T DeyN Ali
May 30, 2014·International Journal of Nanomedicine·Nalinikanth Kotagiri, Jin-Woo Kim
Nov 3, 2007·Nanomedicine·Stavroula Sofou
Aug 3, 1999·Journal of Pharmaceutical Sciences·R C Adami, K G Rice
Oct 13, 2015·Advanced Drug Delivery Reviews·Jung Soo SukLaura M Ensign
Jan 25, 2005·International Journal of Pharmaceutics·S PalakurthiP V Diwan
May 3, 2006·Biomaterials·Arnaud VonarbourgJean-Pierre Benoit
Aug 29, 2009·Biochimica Et Biophysica Acta·Scott R BurksJoseph P Y Kao
Feb 6, 2008·Expert Opinion on Drug Delivery·Stavroula Sofou, George Sgouros
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F Frézard
May 31, 2007·The Journal of Gene Medicine·Feng LiuLeaf Huang
Oct 1, 2005·Journal of Liposome Research·Xuedong YanJan A A M Kamps
Sep 6, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Worapol Ngamcherdtrakul, Wassana Yantasee
Mar 29, 2001·Progress in Lipid Research·G L Scherphof, J A Kamps

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