Serum inhibin B as a marker for spermatogenesis

Archives of Andrology
U C HiplerG Schreiber

Abstract

Inhibin B generated by Sertoli cells provides negative feedback on FSH secretion. In men, inhibin B seems to be the physiologically important form of inhibin. Serum inhibin B was measured by two-site immunoenzymatic assay in 40 normal men (27 years of age) with sperm concentrations 100 +/- 9.2 x 10(6)/mL, 51 subfertile men (31 years of age) with sperm concentrations 6.8 +/- 0.8 x 10(6)/mL, 16 men with varicocele with sperm concentrations 54.3 +/- 0.8 x 10(6)/mL (31 years of age), men with hypogonadotrophic hypogonadism, men with Klinefelter syndrome, and men with obstructive and non-obstructive azoospermia. In men with normal sperm concentrations (>20 x 10(6) mL) serum inhibin B was 201 +/- 17 pg/mL and FSH 4 +/- 0.5 IU/L. Varicocele patients showed normal sperm concentrations > 20 x 10(6)/mL, normal serum inhibin B (173 +/- 21 pg/mL), and normal FSH levels (4.6 +/- 0.6 IU/L). In patients with sperm concentrations < 20 x 10(6)/mL the inhibin B level was 118 +/- 14 pg/mL and the FSH level was 10 +/- 1.1 IU/L. In all patients, except those with hypogonadotrophic hypogonadism and Klinefelter syndrome. inhibin B and FSH were inversely correlated (r = -.41, p > 0.01). There was a positive correlation between inhibin B and sperm conc...Continue Reading

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Citations

Jun 2, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Keith JarviVictor Mak
Nov 18, 2008·The Journal of Urology·Richard LeeSteven S Witkin
Nov 14, 2008·Fertility and Sterility·Gavin M MyersMark Sigman
Apr 15, 2016·PloS One·Thomas W KelseyW Hamish B Wallace
Mar 11, 2010·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Andreas BarthelGeorg Benker
Mar 17, 2007·Archives of Andrology·Antonio ManciniElisabetta Meucci
Jun 4, 2020·Scientific Reports·Emre Yağmur ArıcanGül Özhan

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