PMID: 11925393Apr 2, 2002Paper

Serum inhibin B cannot predict testicular sperm retrieval in patients with non-obstructive azoospermia

Human Reproduction
V VernaeveP Devroey

Abstract

Serum inhibin B, a direct product of the Sertoli cells, may serve as a marker of spermatogenesis. The present retrospective study aimed at evaluating the predictive value of inhibin B for retrieving testicular sperm in non-obstructive azoospermic men. The serum inhibin B concentration before sperm retrieval was reviewed in 185 non-obstructive azoospermic patients. Testicular sperm were successfully recovered in 92 of 185 patients (49.7%). The mean inhibin B concentration in these patients was 37.3 pg/ml. No sperm were found in 93 patients (50.3%), and the mean serum inhibin B concentration was 44.9 pg/ml. The discrimination between successful and unsuccessful sperm retrieval was analysed using the receiver operating characteristics (ROC) curve analysis. The best discriminating inhibin B concentration was 13.7 pg/ml (sensitivity 44.6%, specificity 63.4%) with an area under the ROC curve (AUC) of 0.51. Combining both serum FSH and inhibin B did not improve the predictive value: the AUC of inhibin B in men with a serum FSH concentration <25 and > or = 25 IU/l (being the best threshold value in the population studied) was respectively 0.53 and 0.50. The AUC of the inhibin B:FSH ratios was 0.55. This analysis shows that inhibin B, e...Continue Reading

Citations

Aug 7, 2012·International Urology and Nephrology·Hasan Cem IrkilataMurat Dayanc
Sep 24, 2004·Gynécologie, obstétrique & fertilité·V VernaeveH Tournaye
Nov 29, 2011·Asian Journal of Andrology·Tomomoto Ishikawa
Nov 29, 2011·Asian Journal of Andrology·Natalya A Lopushnyan, Thomas J Walsh
Dec 2, 2010·Human Fertility : Journal of the British Fertility Society·Herman Tournaye
Apr 16, 2003·Annals of Medicine·Frank H PierikRobertus F A Weber
Sep 17, 2010·Actas urologicas españolas·X Ruiz PlazasP Pizá Reus
Apr 22, 2008·The Urologic Clinics of North America·Stephanie E Harris, Jay I Sandlow
May 9, 2008·Gynécologie, obstétrique & fertilité·N Bourcigaux, S Christin-Maître
Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Akira Tsujimura
Mar 6, 2015·European Journal of Endocrinology·Anne-Laure BarbotinValerie Mitchell
Jun 24, 2016·Human Fertility : Journal of the British Fertility Society·Adrija Kumar DattaGillian Lockwood
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Jun 21, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mete IsikogluMurat Seleker
May 2, 2018·Arab Journal of Urology·Rupin Shah, Chirag Gupta
Oct 31, 2019·Human Reproduction Update·Giovanni CoronaNikolaos Sofikitis
Oct 8, 2019·Expert Review of Endocrinology & Metabolism·Jonathan FainbergPeter N Schlegel
Jun 11, 2020·International Urology and Nephrology·Muhammad A ArshadSandro C Esteves
Sep 21, 2005·Human Reproduction Update·Lise AksglaedeAnders Juul

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