Serum insulin-like growth factor binding protein-3 responds differently to trauma in men and women

Critical Care Medicine
M S Houston-BolzeJ H Williford

Abstract

Insulin-like growth factor-1 (IGF-1) has been studied as a marker of nutrition in critical illness, but there is little research on IGF-binding protein-3, which regulates the bioactivity of IGF-1. The objectives of the present study were to measure serum IGF-binding protein-3 concentrations in trauma patients and to determine whether factors such as age, gender, and severity of injury should be considered when evaluating serum IGF-binding protein-3 concentrations as a marker of nutritional or clinical status. Prospective, randomized, descriptive study. Emergency room of a university hospital. One hundred eight trauma patients. None. In this diverse group of patients, Injury Severity Score ranged from 1 to 45 (11.5 +/- 10.3 [SD]), age ranged from 18 to 77 yrs (35 +/- 15.3), and 68% were male. A venous blood sample was collected at the time of admission into the study and was analyzed for serum IGF-binding protein-3 concentration (by radioimmunoassay), serum osmolality, IGF-1 concentration, and C-reactive protein concentration. Relationships between variables were tested using Pearson's correlation coefficients and multiple regression analysis. Age, Injury Severity Score, serum osmolality, time since injury, and gender were not s...Continue Reading

References

Jul 1, 1978·American Journal of Surgery·A B GazzanigaA T Day
Nov 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·M JeevanandamS R Petersen
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·P HossenloppM Binoux
Dec 1, 1986·The Journal of Clinical Investigation·R C Baxter, J L Martin

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Citations

May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·I T Campbell
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·G Minard, K A Kudsk
Nov 26, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Kinjal N SethuramanLena M Napolitano
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·R C Baxter

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