Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases

Endocrine
Subburaman Mohan, David J Baylink

Abstract

Because impaired bone formation is a major contributor to the pathogenesis of senile (type II) osteoporosis, and because insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation in vitro and in vivo, studies have been focused towards clarifying the role of IGF system in the age-related impairment in bone formation. To evaluate if changes in circulating and bone cell production of IGF binding protein (IGFBP)-4 and IGFBP-5 could contribute to age-related impairment in bone formation, the authors measured serum and skeletal levels of IGFBP-5, and serum levels of IGFBP-4 during aging. Circulating levels of IGFBP-4 increased with age, whereas that of IGFBP-5 declined with age. Serum IGFBP-4 and IGFBP-5 levels showed significant positive correlations with serum levels of parathyroid hormone (PTH) and IGFs, respectively. In addition, skeletal content of IGFBP-5 declined with age. The age-related changes in IGFBP-4 and IGFBP-5 production could contribute, in part, to the decrease in osteoblast cell proliferation and deficiency in bone formation.

References

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Citations

Nov 19, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kristen E GovoniSubburaman Mohan
Mar 22, 2006·Journal of Neural Transmission·J V LafuenteB Mitre
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Oct 9, 2007·Archives of Physiology and Biochemistry·A HoeflichD Kiepe
Aug 31, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John L FowlkesCharles K Lumpkin
Apr 8, 2018·Journal of Molecular Endocrinology·Shoshana YakarClifford J Rosen
Mar 23, 2018·Journal of Molecular Endocrinology·David R Clemmons
Aug 4, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joshua N Farr, Maria Almeida
Feb 1, 2002·The Journal of Biological Chemistry·Yousef G AmaarSubburaman Mohan
Jun 1, 2018·Scientific Reports·Claire H KimA Heather Eliassen
Oct 25, 2017·Tissue Engineering and Regenerative Medicine·Manabu AkahaneYasuhito Tanaka

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