Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
G BedogniS Cianfarani

Abstract

Insulin-like growth factor I (IGF-I) measurement is widely used for the diagnosis of disorders of GH secretion and sensitivity, and for monitoring of both GH and IGF-I replacement therapies. However, the lack of appropriate reference values obtained from large and representative samples undermines its practical utility. To establish IGF-I reference values for a commonly used enzyme-labeled chemiluminescent immunometric assay in a large population of children aged 0 to 18 years. Cross-sectional analysis of serum IGF-I levels from samples collected in the two major Italian Children's Hospitals. IGF-I was measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay in 24403 children (50.6% girls) aged 0 to 18 years. Quantile regression coupled to multivariable fractional polynomials was used to produce age- and sex-specific reference values. Age- and sex-specific IGF-I reference values. Reference values for immunometric assay of IGF-I were produced in a large sample of children and adolescents. Prediction equations were provided to automatize their calculations.

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Citations

Sep 4, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·María Gabriela BalleriniMaría Gabriela Ropelato
Nov 8, 2014·Journal of Endocrinological Investigation·C BizzarriS Cianfarani
Aug 30, 2016·Endocrine Journal·Zhi-Hong LiaoYan-Bing Li
Jun 2, 2017·Hormone Research in Pædiatrics·Elena InzaghiStefano Cianfarani
Mar 15, 2014·Expert Opinion on Biological Therapy·Samuel P Mandell, Nicole S Gibran
May 24, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·P G BruniG Campanelli
Jun 21, 2017·American Journal of Medical Genetics. Part a·Paola CambiasoMarina Macchiaiolo
Oct 2, 2020·Journal of Endocrinological Investigation·C BizzarriM Cappa
Aug 4, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J X LuQ Zhang
Apr 1, 2021·Molecular Genetics & Genomic Medicine·Maria Elisa AmodeoStefano Cianfarani

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