Serum insulin-like growth factors (IGFs) and IGF binding proteins 1, 2, and 3 in children with chronic renal failure: relationship to height and glomerular filtration rate. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood

The Journal of Clinical Endocrinology and Metabolism
B TönshoffO Mehls

Abstract

Serum levels of insulin-like growth factor I (IGF-I), IGF-II, and IGF binding protein 1 (IGFBP-1), IGFBP-2, and IGFBP-3 were measured in 94 children with chronic renal failure (CRF). The results were compared with their respective age-dependent normal ranges, and the relationship with height and residual glomerular filtration rate (GFR) was examined. Each IGF and IGFBP was quantified by specific RIA. Serum IGF-I and IGF-II levels were in the normal range throughout their entire childhood in the vast majority of cases. The mean age-related IGF-I (0.07 +/- 0.14 SD score) and IGF-II levels (0.06 +/- 0.11 SD) were similar. Age-related IGF-II but not IGF-I levels showed a weak inverse linear correlation with residual GFRs (r = -0.24, P < 0.02). Mean age-related IGFBP-1 serum levels (1.04 +/- 0.09 SD) were slightly elevated, whereas mean age-related serum IGFBP-2 levels (3.25 +/- 0.20 SD) and serum IGFBP-3 levels (2.61 +/- 0.12 SD) were markedly elevated. Significant inverse correlations were found between GFRs and age-related IGFBP-1 (r = -0.42, P < 0.001), IG-FBP-2 (r = -0.56, P < 0.001), and IGFBP-3 (r = -0.28, P < 0.005), but the increase in IGFBP-2 with declining GFR was relatively more pronounced than the respective increase in...Continue Reading

Citations

Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
Oct 13, 2006·Journal of Endocrinological Investigation·K MüssigH J Quabbe
Sep 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Victoria Schebek-FürstenbergBernd Kübler
Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Burkhard TönshoffSonia Ciarmatori
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Daniela KiepeBurkhard Tönshoff
May 3, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Reinhard FenebergJohannes D Veldhuis
May 14, 2008·World Journal of Gastroenterology : WJG·Jing ZhouZhi-Xiang Shen
May 7, 2016·World Journal of Nephrology·Juan TuRobert H Mak
Feb 12, 2004·Pediatric Transplantation·Philip D Acott, Jeffrey M Pernica
Feb 15, 2007·The British Journal of Nutrition·R RashidS F Ahmed
Sep 29, 2011·Nature Reviews. Nephrology·Lesley Rees, Robert H Mak

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