PMID: 6988933Feb 1, 1980Paper

Serum insulin response to oral glucose load during a dietary intervention trial in healthy coronary high risk men: the Oslo study

Scandinavian Journal of Clinical and Laboratory Investigation
I HjermannI Holme

Abstract

The effect of an ordinary lipid-lowering diet on serum insulin response to oral glucose load was investigated in a randomized, primary preventive trial of the Oslo Study of coronary heart disease in healthy high risk middle aged men. After 3 years intervention the treated group showed a significantly lower insulin response curve, a lower serum total cholesterol, a higher cholesterol ratio (defined as the ratio between high density lipoprotein cholesterol and low density + very low density lipoprotein cholesterol), lower fasting triglycerides and lower relative body weight than the control group. Increased levels of serum insulin and elevated insulin response to oral glucose load has been shown in earlier studies to be associated with increased susceptibility for atherosclerotic diseases. Therefore, it might be of importance, that lipid-lowering diet induce a lowering of serum insulin response in healthy, coronary prone men. As a contrast to the two high risk groups, the very low response curve of serum insulin and glucose in a group of coronary low risk men is also presented, and it is suggested that serum insulin levels should be added to the coronary prone syndrome of hyperlipidemia, obesity and physical inactivity.

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Citations

Oct 19, 1991·BMJ : British Medical Journal·L E RamsayP R Jackson
Jul 1, 1992·Annals of Epidemiology·I Hjermann
Dec 10, 2003·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Torben JørgensenCharlotta Pisinger
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Neil A SmartNigel Kwok
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 2, 2020·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R L ThompsonS Ebrahim
Mar 26, 2014·Nature Reviews. Cardiology·Nathan D Wong

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