Serum interferon-related microRNAs as biomarkers to predict the response to interferon therapy in chronic hepatitis C genotype 4

PloS One
Tarek M K MotawiMahmoud Ahmed Senousy

Abstract

MicroRNAs are messengers during interferon-virus interplay and are involved in antiviral immunity, however, little is known about interferon-related microRNAs regarding their detection in serum and their potential use as non-invasive diagnostic and prognostic biomarkers in chronic hepatitis C (CHC). To elucidate some of the molecular aspects underlying failure of pegylated interferon-α/ribavirin therapy, we investigated pretreatment expression profiles of seven selected interferon-related microRNAs (miR-146a, miR-34a, miR-130a, miR-19a, miR-192, miR-195, and miR-296) by quantitative RT-PCR custom array technology in serum of Egyptian CHC genotype 4 patients and whether their pretreatment levels would predict patient response to the combination therapy. One hundred and six CHC patients and forty matched healthy controls were included. Patients were divided into sustained virological response (SVR) and non-responder (NR) groups. Serum miR-34a, miR-130a, miR-19a, miR-192, miR-195, and miR-296 were upregulated, whereas serum miR-146a was downregulated in CHC compared to controls. Significant correlations were found between expression levels of studied microRNAs and also with clinical data. Pretreatment levels of miR-34a, miR-130a, ...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Jul 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Glenn RandallCharles M Rice
Oct 19, 2007·Nature·Irene M PedersenMichael David
Nov 13, 2007·Cancer Cell·Heiko Hermeking
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pantxika Bellecave, Darius Moradpour
Jan 6, 2009·Nature Medicine·Magdalena Sarasin-FilipowiczWitold Filipowicz
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kai WangDavid J Galas
Dec 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Nabil AntakiPatrick Marcellin
Jan 1, 2009·Journal of Global Infectious Diseases·Luis Jesuino de Oliveria AndradeRaymundo Paraná
Sep 10, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Nury M SteuerwaldHerbert L Bonkovsky
Oct 26, 2010·BMC Medical Genomics·Yoshiki MurakamiKunitada Shimotohno
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Sanaa M Kamal
Jun 23, 2011·Journal of Viral Hepatitis·F JiP Tien
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team
Jun 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shashi BalaGyongyi Szabo
Aug 1, 2012·Journal of Translational Medicine·Shashi BalaGyongyi Szabo
Oct 3, 2012·International Journal of Oncology·Alessandro AllegraCaterina Musolino
Apr 4, 2013·Scientific Reports·Shivaprasad ShwethaSaumitra Das
Apr 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tung-Hung SuDing-Shinn Chen
Jun 27, 2013·BMC Infectious Diseases·Yousra A MohamoudLaith J Abu-Raddad
Jul 31, 2013·PloS One·Aideen S CollinsNigel J Stevenson
Jul 31, 2013·Experimental and Molecular Pathology·Yuan MuYiting Zhang
Dec 11, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Youngwook KimKeunchil Park
Mar 5, 2014·The Pharmacogenomics Journal·A N BurskaF Ponchel

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
biopsy
genotyping

Software Mentioned

GraphPad Prism
Metavir Scoring System
Statistical Package for the Social Science ( SPSS

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.