Serum Interleukin-15 is a Marker of Alopecia Areata Severity

International Journal of Trichology
Adel Ali EbrahimEsraa Taha Younis

Abstract

Interleukin-15 (IL-15) is a cytokine that is involved in many inflammatory and autoimmune diseases. Although alopecia areata (AA) is an autoimmune disease, serum levels of IL-15 have not been studied well in AA patients. We aims at evaluating the serum levels of IL-15 in active AA. This case-control study included 40 AA patients and 40 apparently healthy matched controls. Written informed consents were obtained from all the participants. The scalp was examined to assess sites, number, and size of alopecia patches, and the severity of AA lesions was assessed using the Severity of Alopecia Tool score (SALT score) which determine the percentage of hair loss in the scalp. The body was carefully examined to detect any alopecia patches in any hairy area. Nail examination was carried out to detect any nail involvement. Serum IL-15 levels were measured using an ELISA kits. Serum levels of IL-15 in patients were significantly higher than those in the control group (P < 0.001). Serum levels in alopecia totalis were significantly higher than those with one or two patches, and serum levels in patients with both scalp and body involvement were significantly elevated than the levels of patients with either scalp or body involvement. There wa...Continue Reading

References

Jul 20, 2018·Science Translational Medicine·Jillian M RichmondJohn E Harris

❮ Previous
Next ❯

Citations

Jul 19, 2020·Experimental Dermatology·Marta BertoliniRalf Paus
Oct 14, 2019·The Journal of Allergy and Clinical Immunology·Amos GilharRalf Paus
Dec 29, 2020·Journal of Cosmetic Dermatology·Mona A AtwaRadwa El-Sayed Mahmoud Marie
Aug 6, 2021·ImmunoTargets and Therapy·Poonkiat SuchonwanitCherrin Pomsoong
Nov 4, 2021·Journal of Cosmetic Dermatology·Sahar Taha Hatif AldaffaieAli Abd Razzak Muhieldden

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.