Serum interleukin-34 levels in patients with systemic sclerosis: Clinical association with interstitial lung disease.

The Journal of Dermatology
Ai KuzumiShinichi Sato

Abstract

Interleukin (IL)-34 is a hematopoietic cytokine promoting proliferation and differentiation of macrophages. Because abnormal activation of macrophages is involved in the development of systemic sclerosis (SSc), we investigated serum IL-34 levels in patients with SSc. Serum IL-34 levels were significantly increased in diffuse cutaneous SSc compared with limited cutaneous SSc and healthy controls, while there were no significant differences between limited cutaneous SSc and healthy controls. In addition, SSc patients with increased serum IL-34 levels more often had interstitial lung disease (ILD) than those with normal levels. Moreover, in SSc patients, serum IL-34 levels negatively correlated with the percentage of predicted vital capacity, while they positively correlated with ground-glass opacity score and fibrotic score on chest computed tomography. Collectively, increased serum IL-34 levels were associated with greater frequency and severity of ILD in SSc patients. Serum IL-34 levels may be a useful serological marker for SSc-associated ILD.

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Citations

Jun 8, 2019·Journal of Cellular Physiology·Wang-Dong XuLin-Chong Su
Dec 12, 2019·International Journal of Rheumatic Diseases·Yanmei LiuHui Shen
Apr 10, 2020·Journal of Crohn's & Colitis·Eleonora FranzèGiovanni Monteleone
Jul 12, 2019·Frontiers in Immunology·Anne M StevensFrancesco Zulian
Mar 3, 2020·The Lancet. Respiratory Medicine·Apostolos PerelasKristin B Highland
Apr 4, 2021·International Journal of Molecular Sciences·Muna PoudelHong Seok Choi

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