PMID: 12786682Jun 6, 2003Paper

Serum interleukin-6 levels and bone mineral density at the femoral neck in post-menopausal women with Type 1 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
D RachońW Łysiak-Szydłowska

Abstract

Although osteopenia is often reported in Type 1 diabetes mellitus, the pathogenic mechanisms are not fully understood. Oestrogen deficiency also leads to decreased bone mineral density (BMD). Enhanced interleukin-6 (IL-6) production among Type 1 diabetic patients could be involved in the pathogenesis of diabetic bone loss since it is a potent bone resorbing cytokine. To evaluate the relationship between serum bioactive IL-6 levels and BMD at the femoral neck of post-menopausal women with Type 1 diabetes. We studied BMD, urine excretion of deoxypirydynoline crosslinks, serum bioactive IL-6 and soluble IL-6 receptor (sIL-6R) levels in 20 post-menopausal women with Type 1 diabetes mellitus, and compared these results with 20 matched healthy post-menopausal controls. Post-menopausal women with Type 1 diabetes had significantly lower BMD at the femoral neck and increased serum bioactive IL-6 levels compared with the control group, but no relationship was observed between these variables in a multiple regression analysis. Using BMD at the femoral neck of diabetic women as the dependent variable in the multiple step regression analysis model, we found that independent variables that were strongly associated with bone mass at the femor...Continue Reading

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Citations

Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Oct 4, 2003·Cardiovascular Diabetology·Enrique Z FismanAlexander Tenenbaum
Oct 13, 2010·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
Sep 19, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·M Orhun CamurdanFatma Demirel
Oct 6, 2016·Current Osteoporosis Reports·Evangelia KalaitzoglouKathryn M Thrailkill
May 8, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N Jiang, W Xia
Sep 3, 2003·Diabetes/metabolism Research and Reviews
Jun 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V N ShahW M Kohrt

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