PMID: 11899364Mar 20, 2002Paper

Serum interleukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients

Clinical Breast Cancer
Ina BenoyLuc Y Dirix

Abstract

Serum and plasma concentrations of vascular endothelial growth factor (sVEGF and pVEGF), serum concentrations of interleukin 6 (IL-6), and VEGF platelet load (VEGF/pl) in the blood of healthy controls (n = 26), breast cancer patients with locoregional disease (n = 31), and patients with progressive advanced disease (n = 73) have been compared. The 95th percentile values for the control population were 250 pg/mL for sVEGF, 30 pg/mL for pVEGF, and 1.6 pg/mL for IL-6. The 95th percentile value of the calculated VEGF/pl was 1.0 pg/10(6) platelets in the control population. Serum VEGF concentrations correlated with platelet number in all the groups. Patients with thrombocytosis had a median sVEGF concentration of 833 pg/mL, compared to 249 pg/mL in other patients (P = 0.018). Serum IL-6 levels correlated with sVEGF levels and with the calculated VEGF/pl. Serum IL-6 concentration was significantly higher in patients with breast cancer compared to healthy controls (P < 0.0001). Median IL-6 serum levels were nearly 10 times higher in patients with metastatic breast cancer as compared to the those with locoregional disease (6.0 pg/mL versus 0.7 pg/mL, respectively). Plasma VEGF and the VEGF/pl were also significantly different in the 3 ...Continue Reading

Citations

Nov 28, 2002·British Journal of Cancer·R SalgadoL Y Dirix
Jun 11, 2008·Clinical & Experimental Metastasis·Ravi DhurjatiErwin A Vogler
Nov 7, 2008·Cancer Causes & Control : CCC·Katherine W ReevesJane A Cauley
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Robert PartykaTomasz Byrczek
Jul 19, 2013·International Journal of Breast Cancer·Athina Stravodimou, Ioannis A Voutsadakis
Dec 4, 2014·Obstetrics & Gynecology Science·Antonia Digklia, Ioannis A Voutsadakis
Aug 1, 2007·Proteomics. Clinical Applications·Zhaojing Meng, Timothy D Veenstra
Aug 14, 2008·Expert Review of Anticancer Therapy·Lubor Borsig
Nov 10, 2017·Journal of Cellular Biochemistry·Márcia F C J PazJuliana da Silva
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Roberto SalgadoLuc Y Dirix
Mar 5, 2005·European Journal of Endocrinology·S A BorgT H Jones
Aug 18, 2005·BJU International·Jonathan E KatzDavid B Agus
Apr 10, 2008·Pathology Oncology Research : POR·Anna ThielemannAleksandra Baszczuk
Jan 31, 2007·Breast Cancer Research : BCR·Carine ChaveyGwendal Lazennec
Aug 13, 2014·World Journal of Clinical Oncology·Sibel Eyigor, Selcen Kanyilmaz
Sep 10, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andrew P GoodwinRobert F Mattrey
Feb 2, 2017·World Journal of Gastrointestinal Oncology·Morgan Steele, Ioannis A Voutsadakis
Oct 5, 2007·Blood·David CerviGiannoula L Klement
Aug 21, 2010·International Journal of Cancer. Journal International Du Cancer·Wiltrud LederleMargareta M Mueller
Oct 9, 2009·Immunological Investigations·Sarah KimAngela DeMichele
Jun 1, 2008·Expert Opinion on Medical Diagnostics·Magdalena ChechlinskaJanina Kaminska
Jan 15, 2013·Journal of Skin Cancer·Kunal SonavaneCherie-Ann O Nathan
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yasemin KemalMeltem Ozdemir
Dec 9, 2003·Journal of Applied Physiology·Raymond M KrausTimothy P Gavin

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