PMID: 589005Sep 1, 1977

Serum ionized calcium in acute pancreatitis

The British Journal of Surgery
B F Allam, C W Imrie


Measurement of serum ionized calcium was performed daily for 7 days after admission in 8 consecutive patients with acute pancreatitis. The results support the findings of our previous study that the most common cause of the low serum calcium often found in patients with this disease is a low serum albumin; when correction of serum calcium is made for hypo-albuminanemia, most patients are found to be normocalcaemic. The occasional hypocalcaemia as shown by the 'corrected' serum calcium or by serum ionized calcium measurement is usually mild and transient, indicating that the normal homoeostatic mechanisms of the body can efficiently maintain the physiologically active fraction of the serum calcium within, or close to, the normal range. These findings explain the rarity of overt and subclinical tetany in acute pancreatitis. This study has shown that correction of serum calcium for albumin provides similar information to the direct measurement of serum ionized calcium. The value of 'apparent' hypocalcemia in assessing severity of acute pancreatitis requires reappraisal, while greater attention should be directed towards the investigation and management of hypoalbuminaemia in this disease.


Mar 4, 1976·The New England Journal of Medicine·G M RobertsonH L Estep
Jun 1, 1975·The British Journal of Surgery·C W Imrie, A S Whyte
Feb 1, 1975·The British Journal of Surgery·J R CondonJ Day
Aug 1, 1975·Annals of Internal Medicine·G C WeirA L Warshaw
Jan 1, 1976·Current Medical Research and Opinion·C W ImrieJ C Ferguson
Sep 1, 1973·British Journal of Anaesthesia·C T Flear, C M Singh
Jul 20, 1974·Lancet·C T Flear
Jan 1, 1968·Archives of Surgery·A F Cortese, F Glenn
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Putman
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F S TanzerR V Talmage
Jun 1, 1971·Annals of Internal Medicine·E P Cortes
Mar 1, 1966·The British Journal of Surgery·M R Wills
Jun 1, 1966·The Surgical Clinics of North America·G L Nardi
Jan 1, 1967·Metabolism: Clinical and Experimental·E PaloyanP V Harper
Jan 1, 1952·The American Journal of Medicine·H A EDMONDSONM WERTMAN


Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·W G Robertson, R W Marshall
Dec 1, 1984·Current Problems in Surgery·A L Warshaw, J M Richter
Jun 1, 1981·The Australian and New Zealand Journal of Surgery·M ParoulakisC Mullany
May 1, 1979·American Journal of Surgery·C F Frey
Feb 6, 2004·Revista Do Instituto De Medicina Tropical De São Paulo·Elizabeth De Francesco DaherRégia Maria do Socorro Vidal Patrocínio
Oct 1, 1978·The British Journal of Surgery·C W ImrieA J McKay
May 1, 1978·The British Journal of Surgery·C W ImrieL H Blumgart
Mar 1, 1994·The British Journal of Surgery·C McKayJ N Baxter
Apr 1, 1986·The British Journal of Surgery·M G Shearer, C W Imrie
Apr 1, 1981·The British Journal of Surgery·R S CrotonN B Roberts
Feb 1, 1982·The British Journal of Surgery·M J McMahonJ S Woodhead
Mar 15, 1986·British Medical Journal·M J Waterson, M N Fahie-Wilson

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