PMID: 589005Sep 1, 1977

Serum ionized calcium in acute pancreatitis

The British Journal of Surgery
B F Allam, C W Imrie

Abstract

Measurement of serum ionized calcium was performed daily for 7 days after admission in 8 consecutive patients with acute pancreatitis. The results support the findings of our previous study that the most common cause of the low serum calcium often found in patients with this disease is a low serum albumin; when correction of serum calcium is made for hypo-albuminanemia, most patients are found to be normocalcaemic. The occasional hypocalcaemia as shown by the 'corrected' serum calcium or by serum ionized calcium measurement is usually mild and transient, indicating that the normal homoeostatic mechanisms of the body can efficiently maintain the physiologically active fraction of the serum calcium within, or close to, the normal range. These findings explain the rarity of overt and subclinical tetany in acute pancreatitis. This study has shown that correction of serum calcium for albumin provides similar information to the direct measurement of serum ionized calcium. The value of 'apparent' hypocalcemia in assessing severity of acute pancreatitis requires reappraisal, while greater attention should be directed towards the investigation and management of hypoalbuminaemia in this disease.

References

Mar 4, 1976·The New England Journal of Medicine·G M RobertsonH L Estep
Jun 1, 1975·The British Journal of Surgery·C W Imrie, A S Whyte
Feb 1, 1975·The British Journal of Surgery·J R CondonJ Day
Aug 1, 1975·Annals of Internal Medicine·G C WeirA L Warshaw
Jan 1, 1976·Current Medical Research and Opinion·C W ImrieJ C Ferguson
Sep 1, 1973·British Journal of Anaesthesia·C T Flear, C M Singh
Jul 20, 1974·Lancet·C T Flear
Jan 1, 1968·Archives of Surgery·A F Cortese, F Glenn
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Putman
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F S TanzerR V Talmage
Jun 1, 1971·Annals of Internal Medicine·E P Cortes
Mar 1, 1966·The British Journal of Surgery·M R Wills
Jun 1, 1966·The Surgical Clinics of North America·G L Nardi
Jan 1, 1967·Metabolism: Clinical and Experimental·E PaloyanP V Harper
Jan 1, 1952·The American Journal of Medicine·H A EDMONDSONM WERTMAN

Citations

Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·W G Robertson, R W Marshall
Dec 1, 1984·Current Problems in Surgery·A L Warshaw, J M Richter
Jun 1, 1981·The Australian and New Zealand Journal of Surgery·M ParoulakisC Mullany
May 1, 1979·American Journal of Surgery·C F Frey
Feb 6, 2004·Revista Do Instituto De Medicina Tropical De São Paulo·Elizabeth De Francesco DaherRégia Maria do Socorro Vidal Patrocínio
Oct 1, 1978·The British Journal of Surgery·C W ImrieA J McKay
May 1, 1978·The British Journal of Surgery·C W ImrieL H Blumgart
Mar 1, 1994·The British Journal of Surgery·C McKayJ N Baxter
Apr 1, 1986·The British Journal of Surgery·M G Shearer, C W Imrie
Apr 1, 1981·The British Journal of Surgery·R S CrotonN B Roberts
Feb 1, 1982·The British Journal of Surgery·M J McMahonJ S Woodhead
Mar 15, 1986·British Medical Journal·M J Waterson, M N Fahie-Wilson

Related Concepts

Acute Disease
Calcium
Pancreatitis
Plasma Albumin

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

The New England Journal of Medicine
C Waterhouse, R E Heinig
The American Journal of Digestive Diseases
R R Babb
The Journal of Clinical Endocrinology and Metabolism
S W LambertsT J Visser
© 2021 Meta ULC. All rights reserved