Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation.

Clinica Chimica Acta; International Journal of Clinical Chemistry
Marilena MinieriSergio Bernardini

Abstract

The iPTH upper reference limit (URL) reported by our laboratory provider (Abbott Laboratories) at Tor Vergata University Hospital was evaluated by internal verification procedures as not representative of our population and resulting as underestimated. In this study, a new reference interval has been investigated and established by comparing a direct and an indirect method based on a statistical reduction from results stored in the laboratory database. For reference interval calculation from the healthy population, we analyzed a cohort of 100 blood donors (84% males and 16% females) screened with no bone-related and malabsorption diseases. We analyzed a cohort of 495 patients retrieved from more than 800 iPTH results by excluding subjects with pathological measurement for calcium, phosphorus, and creatinine for the reference interval evaluation. Patients with vitamin D results were included in the analysis. Vitamin D sufficiency status during the period from January to September 2020 was also evaluated by investigating 3,050 patients. The iPTH reference interval of a healthy blood donor population was measured as 25.2-109.1 pg/mL (2.7-11.6 pmol/L) at 2.5 and 97.5 distribution percentile. The iPTH reference interval from data st...Continue Reading

References

Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Paul Glendenning, Samuel D Vasikaran
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Paul S Horn, Amadeo J Pesce
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Apr 11, 2008·Journal of the American Society of Nephrology : JASN·Cédric GauciUNKNOWN NephroTest Study Group
Apr 25, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joan LappeKerry Thompson
May 7, 2008·International Journal of Sport Nutrition and Exercise Metabolism·Kentz S WillisD Enette Larson-Meyer
Jun 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Robert P Heaney
Dec 24, 2008·Annals of Clinical Biochemistry·Ferruccio CeriottiMauro Panteghini
Aug 3, 2010·Mayo Clinic Proceedings·Kurt A KennelDaniel L Hurley
Nov 3, 2010·Clinical Endocrinology·Lars RejnmarkLeif Mosekilde
Feb 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert P Heaney, Michael F Holick
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Etienne CavalierJean-Claude Souberbielle
Sep 10, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·M M L DeckersA C Heijboer
Sep 27, 2013·Nutrients·Fahad Alshahrani, Naji Aljohani
Feb 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Mathilde TouvierJean-Claude Souberbielle
Oct 4, 2016·Journal of Endocrinological Investigation·J-C SouberbielleE Cavalier
Dec 14, 2016·The New England Journal of Medicine·JoAnn E MansonChristine L Taylor
May 19, 2017·Reviews in Endocrine & Metabolic Disorders·Michael F Holick
Aug 5, 2017·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Dimitrios T Papadimitriou
Sep 16, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Jennifer S WalshAmy L Evans
Mar 30, 2018·Frontiers of Hormone Research·David GoltzmanClaudio Marcocci
Sep 16, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Wendy P J den ElzenChrista M Cobbaert
Jul 6, 2019·Journal of Endocrinological Investigation·N YallaR Ostlund
Jan 11, 2020·International Journal of Nephrology and Renovascular Disease·Bala WaziriSaraladevi Naicker
Jan 31, 2020·Current Opinion in Nephrology and Hypertension·Maureen BroganMichal L Melamed
Jul 19, 2020·Nutrients·Nipith Charoenngam, Michael F Holick
Dec 29, 2020·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Magdalena WójtowiczStanisław Niemczyk

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