Abstract
Iron deposition has been noted widely in the subcortical deep gray matter (SDGM) of multiple sclerosis (MS) patients. Recent evidence suggests that serum iron may cross the blood-brain barrier and might be associated with SDGM iron deposition. The aim of the current study was to assess whether an iron-sensitive MRI measure is related to serum iron concentrations. This was a retrospective, cross-sectional study of 22 MS patients and 24 healthy controls (HCs), group matched for age and sex. Participants were imaged on a 1.5-T MRI scanner. High-resolution T1-weighted images and susceptibility-weighted images were acquired for assessing SDGM volumes and iron deposition within the SDGM, respectively. All participants also had blood drawn for the measurement of serum iron concentrations. MS and HC groups were compared with respect to SDGM tissue volumes and iron content. Partial correlations, controlling for age, sex, and structural volume, were used to assess the relationship between serum iron and SDGM iron content. MS patients presented with significantly smaller SDGM tissue volumes of the caudate, globus pallidus, putamen, and thalamus (all P≤0.0001). With respect to HCs, increased iron content was observed for MS patients in the...Continue Reading
References
Sep 1, 1994·Journal of Neurochemistry·M GerlachM B Youdim
Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
May 27, 2006·Metabolic Brain Disease·S J van RensburgR T Erasmus
Jan 9, 2008·NeuroImage·Xiaojun XuMinming Zhang
Nov 29, 2008·AJNR. American Journal of Neuroradiology·E M HaackeY-C N Cheng
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karin ShmueliJeff H Duyn
Jan 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael J HouseJohn K Olynyk
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Karla HoppHelen Nichol
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Jul 26, 2011·Biochimica Et Biophysica Acta·Hyman M Schipper
Aug 9, 2011·NeuroImage·Robert ZivadinovMichael G Dwyer
Oct 7, 2011·Human Brain Mapping·Rose Gelineau-MorelJacqueline Palace
Oct 19, 2011·Journal of Neurochemistry·Rachel WilliamsSteven M LeVine
Mar 17, 2012·Metabolic Brain Disease·Susan J van RensburgRonald van Toorn
Mar 31, 2012·AJNR. American Journal of Neuroradiology·J HagemeierR Zivadinov
Aug 9, 2013·Radiology·Andrew J WalshAlan H Wilman
Jun 6, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Lukas HaiderJosa M Frischer
May 20, 2015·Journal of Magnetic Resonance Imaging : JMRI·Dana CobzasAlan H Wilman
Oct 28, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Md Nasir UddinAlan H Wilman
May 31, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Niels BergslandMarco Rovaris
Dec 21, 2016·Wellcome Open Research·Alex LewinCharles R M Bangham
Citations
Jun 14, 2018·Journal of Magnetic Resonance Imaging : JMRI·Fuhua YanRuokun Li
Jul 18, 2018·Radiology·Robert ZivadinovFerdinand Schweser
Sep 27, 2019·CNS Drugs·Niels BergslandRobert Zivadinov