PMID: 8601722Feb 1, 1996Paper

Serum is a potent stimulator of keratinocyte tissue plasminogen activator expression

The Journal of Investigative Dermatology
C S Chen, P J Jensen

Abstract

The plasminogen activator (PA) proteolytic cascade comprises two enzymes known as urokinase PA (uPA) and tissue PA (tPA), both of which activate plasminogen to plasmin. In normal human epidermis uPA is the predominant PA. In lesional epidermis from patients with a variety of cutaneous diseases, including psoriasis, pemphigus foliaceous, pemphigus, vulgaris, bullous pemphigoid, and benign chronic pemphigus, however, tPA is selectively elevated and becomes the predominant PA activity. The enhanced tPA is likely to be a reaction to the disease challenge rather than an initiating event in these clinically and etiologically diverse lesions. In the present study, cultured human keratinocytes, propagated under serum-free conditions, have been shown to respond to the addition of bovine or human serum with an increase in tPA activity and antigen. Furthermore, tPA is found predominantly in the suprabasal keratinocytes both in lesional epidermis and in stratified cultures that have been incubated for approximately 8 d in the presence of serum. These results suggest a possible mechanism by which epidermal tPA may be increased in diverse cutaneous lesions: The plasma infiltrated into lesional epidermis may stimulate the suprabasal keratinoc...Continue Reading

References

Sep 1, 1992·The British Journal of Dermatology·H M GisslerM D Kramer
Oct 1, 1991·The Journal of Clinical Investigation·J D VassalliD Belin
Jan 1, 1991·Advances in Cancer Research·J PöllänenA Vaheri
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Jun 1, 1988·The Journal of Investigative Dermatology·P J JensenG S Lazarus
Jun 1, 1988·The Journal of Investigative Dermatology·J Grøndahl-HansenK Danø
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Apr 1, 1983·The Journal of Investigative Dermatology·R R Isseroff, D B Rifkin
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Mar 1, 1994·The Journal of Investigative Dermatology·E M SpiersB Lyons-Giordano
Sep 1, 1993·Journal of Cellular Physiology·Y AndoP J Jensen
Apr 1, 1993·The Journal of Investigative Dermatology·J SchalkwijkG J de Jongh

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Citations

Apr 22, 2017·Archives of Dermatological Research·K A RubinaV A Tkachuk
Oct 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·M WeckrothV Sirén
Jun 17, 2006·Journal of Cutaneous Pathology·Alessandro LanzaFernando Gombos
Aug 22, 2003·Experimental Dermatology·Claudio FelicianiAntonio Tulli
Jun 29, 2005·The Journal of Investigative Dermatology·Michele L LokitzVictoria P Werth

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