Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma.

Aging
Xiangyu ZhaiBin Jin

Abstract

Cell proliferation and migration are the determinants of malignant tumor progression, and a better understanding of related genes will lead to the identification of new targets aimed at preventing the spread of cancer. Some studies have shown that KIAA1199 (CEMIP) is a transmembrane protein expressed in many types of noncancerous cells and cancer cells. However, the potential role of KIAA1199 in the progression of cholangiocarcinoma (CCA) remains unclear. Analysis of cancer-related databases showed that KIAA1199 is overexpressed in CCA. ELISA, immunohistochemistry, Western blotting and qPCR indicated high expression levels of KIAA1199 in serum, CCA tissues and CCA cell lines. In the serum (n = 41) and large sample validation (n = 177) cohorts, higher KIAA1199 expression was associated with shorter overall survival and disease-free survival times. At the cellular level, KIAA1199 overexpression (OE) promoted CCA growth and metastasis. Subcutaneous tumor xenograft experiments showed that KIAA1199 enhances CCA cell proliferation. Additionally, the expression levels of components in the EMT-related TGF-β pathway changed significantly after KIAA1199 upregulation and silencing. KIAA1199 is a promising new diagnostic molecule and thera...Continue Reading

References

Sep 2, 1998·Journal of Structural Biology·J JenkinsR Pickersgill
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Feb 22, 2005·American Journal of Surgery·Harald PuhallaThomas Gruenberger
Sep 15, 2005·Cancer Letters·Eriko MichishitaIzumi Horikawa
Jul 17, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brigham C Willis, Zea Borok
May 13, 2008·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaJames M Metz
Aug 8, 2008·Annals of Surgical Oncology·Dietmar TamandlThomas Gruenberger
May 13, 2009·Annals of Surgical Oncology·Shinji MatsuzakiMasaki Mori
Jan 29, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·George N ZografosKostas Karaliotas
Mar 31, 2011·British Journal of Cancer·A Handra-LucaM Goggins
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gia L Tyson, Hashem B El-Serag
Jun 22, 2011·Cell and Tissue Research·Michael K WendtWilliam P Schiemann
Jul 21, 2011·British Journal of Cancer·K Birkenkamp-DemtroderT F Ørntoft
Mar 3, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jesús M BanalesNicholas F LaRusso
Mar 16, 2012·Journal of Cancer Research and Clinical Oncology·Mohammad RaishWoong Shick Ahn
Aug 31, 2013·Journal of the National Cancer Institute·Nikki A EvensenJian Cao
Oct 12, 2013·Archives of Oral Biology·Pitak ChanthammachatParamee Thongsuksai
Oct 22, 2013·Genes & Development·Jeff H Tsai, Jing Yang
Jan 1, 2010·Cancers·Harald J MaierHartmut Beug
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
Mar 4, 2014·Lancet·Nataliya Razumilava, Gregory J Gores
May 31, 2014·Nature Cell Biology·Alain PuisieuxJulie Caramel
Sep 25, 2014·Science Signaling·David M Gonzalez, Damian Medici
May 11, 2015·Mayo Clinic Proceedings·Konstantinos N Lazaridis, Nicholas F LaRusso

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Datasets Mentioned

BETA
KIAA1199

Methods Mentioned

BETA
ELISA
transfection
xenograft
Xenografts
gene knockout
enzyme-linked immunosorbent assay
Protein Assay
Fluorescence

Software Mentioned

ImageJ
GraphPad Prism
SPSS
SignalP
TMHMM Server

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