PMID: 26768155Jan 16, 2016Paper

Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Monika TalarowskaPiotr Gałecki

Abstract

Genes participating in synaptic signalling or plasticity in brain regions such as the prefrontal cortex (PFC) and the hippocampus have been implicated in cognition. Recently, a new gene (KIBRA, WWC1) has been added to this group due to its impact on memory performance. Recurrent depressive disorder (rDD) is a multifactorial disease, that one of the typical features is cognitive impairment. The main objective of this study was to perform an analysis of the KIBRA gene on both mRNA and protein levels in patients suffering from rDD and to investigate the relationship between KIBRA expression and cognitive performance. The study comprised 236 subjects: patients with rDD (n=131) and healthy subjects (n=105, HS). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Both mRNA and protein expression levels of KIBRA gene were significantly higher in healthy subjects when compared to rDD. The presented relationship is clear even after taking age, education and sex of the examined subjects into consideration. No statistically significant relationship was found in the experiments between any of the conducted tests and KIBRA gene expression on mRNA level for bo...Continue Reading

Citations

Aug 25, 2018·Scientific Reports·Ibrahim A AkkouhSrdjan Djurovic
Nov 11, 2019·Pharmacological Reports : PR·Małgorzata KowalczykPiotr Gałecki
Feb 1, 2020·Pharmacological Reports : PR·Małgorzata KowalczykPiotr Gałecki

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