Serum lactate as a marker of mortality in patients with hip fracture: A prospective study

Injury
Murali VenkatesanS Godsiff

Abstract

Outcomes from patients suffering hip fracture remain poor, with 9% mortality at 30 days and 35% at 1 year. Despite robust guidelines these mortality rates have undergone little change. Admission serum lactate in patients with sepsis or suffering general trauma has been shown to be an indicator of adverse clinical outcomes. We investigated whether venous lactate can predict mortality for hip fracture patients. Over a 12-month period the admission venous lactate of all patients presenting to our institution with hip fractures was prospectively collated. Demographic and patient survivorship data were also prospectively recorded. Multivariate binary logistic regression and Cox proportional hazards ratio analysis was used to evaluate the relationship between admission venous lactate and 30-day mortality and early survivorship, whilst adjusting for age and gender. 770 patients were included in the study. The mean age was 80 years. The overall 30-day mortality for this cohort was 9.5%. Admission venous lactate was associated with early death. A 1mmol/L increase in venous lactate resulted in a 1.9 (95% CI 1.5-2.3 p<0.0001) fold increase in the odds of 30-day mortality and a 1.4 (95% CI: 1.2-1.6 p<0.0001) factor increase in the risk of ...Continue Reading

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Citations

May 6, 2017·BMJ Open·Brett RocosMichael B Kelly
Jan 13, 2018·European Journal of Applied Physiology·Brian S FergusonL Bruce Gladden
Apr 3, 2020·Acta Anaesthesiologica Scandinavica·Magnus H JonssonPeter Bentzer
May 3, 2020·The Journal of Physiology·Brian GlancyL Bruce Gladden
Aug 23, 2019·Infectious Diseases·Julian VillarGeoffrey Lighthall
Oct 3, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Magnus H JonssonPeter Bentzer

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