Abstract
To determine serum laminin concentrations in patients with uncomplicated Plasmodium falciparum malaria. An enzyme linked immunosorbent assay (ELISA) was used to determine serum laminin concentrations in 54 patients with acute uncomplicated P falciparum malaria during and after treatment, and in 17 control subjects in Bangkok, Thailand. Raised concentrations of soluble laminin were observed in patients (mean (SD) concentration 628 (225) ng/ml), compared with normal controls (490 (116) ng/ml), during the acute phase of the disease. During treatment, serum laminin concentrations decreased and returned to normal within three days. Serum laminin concentrations were correlated with parasite counts before treatment, and with the serum concentration of soluble intercellular adhesion molecule-1 (ICAM-1), soluble E-selectin, and soluble tumour necrosis factor receptor at 55 kilodaltons. These findings are compatible with an increased production or release of laminin in P falciparum malaria, which could indicate a role for the subendothelial basement membrane in the pathogenesis of the disease.
References
Feb 1, 1979·Cell·A E ChungB Carlin
Oct 1, 1992·The Journal of Infectious Diseases·P KernF Porzsolt
Oct 1, 1992·The Journal of Experimental Medicine·C F OckenhouseR R Lobb
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·E R Parise, H Rosa
Jan 1, 1992·Urologia Internationalis·K M AbouFarhaR A Janknegt
Jul 1, 1991·The Journal of Infectious Diseases·C F OckenhouseH K Webster
Jul 1, 1991·Annals of the Rheumatic Diseases·N G GusevaV A Nassonova
Jul 14, 1989·Cell·P OquendoB Seed
Sep 7, 1989·Nature·A R BerendtK Marsh
Jun 15, 1989·The New England Journal of Medicine·G E GrauP H Lambert
Aug 1, 1989·The American Journal of Medicine·P KernM Dietrich
Aug 1, 1986·The Journal of Pathology·D R Abrahamson
Dec 1, 1988·Arthritis and Rheumatism·A GabrielliR Timpl
Jan 1, 1987·Annual Review of Cell Biology·G R Martin, R Timpl
Jul 25, 1981·Journal of Molecular Biology·J EngelR Timpl
Jan 1, 1993·Scandinavian Journal of Immunology·R HershkovizO Lider
Jul 1, 1993·Gut·J CollazosJ Genollá
Jan 1, 1993·Urologia Internationalis·K M Abou FarhaJ W Arends
Citations
Sep 1, 1996·Journal of Clinical Immunology·H BurgmannW Graninger
Dec 3, 1999·European Journal of Clinical Investigation·E PresterlW Graninger
Jun 1, 1996·Journal of Clinical Pathology·H BurgmannW Graninger
Sep 9, 2005·European Journal of Haematology·Georgia MetzgerothJan Hastka
Nov 13, 2015·Scientific Reports·Manas KotepuiNuoil Phiwklam
Oct 27, 2017·Scientific Reports·Almahamoudou MahamarMichal Fried
Apr 22, 2021·MSystems·Parnika MukherjeeEmanuel Heitlinger