Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation

Clinical Endocrinology
G A RobertsJ P Miell

Abstract

Leptin, the product of the ob gene, is a postulated feedback regulator of adiposity with appetite suppressant and catabolic effects. Catabolic states are associated with decreased body fat mass as a result of both nutritional and metabolic perturbation. Low serum leptin has been described previously in a number of catabolic states. It has been unclear whether the observed changes in leptin are a cause or consequence of changes in adiposity. Paediatric end-stage liver disease (ESLD) is characterized by decreased body fat mass and poor linear growth. Successful treatment by orthotopic liver transplantation (OLT) is accompanied by increase in fat mass. We investigated the hypothesis that serum leptin would be low in paediatric ESLD and that increase in body fat mass post-OLT would result in increased serum leptin. Serum leptin and insulin were measured by radioimmunoassay in children with ESLD before and after successful OLT and in age-matched controls. Twenty-four children with ESLD attending the outpatient department of King's College Hospital, London and 10 age-matched controls. Anthropometric measurements were performed according to standard techniques and standard deviation (SDS) derived from population standards. Serum lepti...Continue Reading

References

Mar 1, 1976·Archives of Disease in Childhood·J M Tanner, R H Whitehouse
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J MüllerF W Schmidt
Jul 1, 1992·The American Journal of Clinical Nutrition·S E ChinR Strong
Jan 1, 1991·Annals of Surgery·R W BusuttilA Nyerges
Nov 1, 1981·The American Journal of Clinical Nutrition·A R Frisancho
Sep 1, 1995·The Journal of Clinical Investigation·R C FrederichJ S Flier
Sep 5, 1995·Biochemical and Biophysical Research Communications·J RentschM Chiesi
Feb 15, 1996·Nature·G H LeeJ M Friedman
Feb 27, 1996·Biochemical and Biophysical Research Communications·R B LynnJ F Caro
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E ShmueliC O Record
Nov 1, 1996·The Journal of Clinical Endocrinology and Metabolism·S GrinspoonA Klibanski
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J P MiellW F Blum
Feb 1, 1997·The American Journal of Clinical Nutrition·R I HoltG Mieli-Vergani

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Citations

Jul 25, 2000·Journal of Hepatology·R TestaT Barreca
Jan 8, 2008·Acta Paediatrica·Sittisak HonsawekYong Poovorawan
Feb 3, 2000·Critical Reviews in Clinical Laboratory Sciences·J Himms-Hagen

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