Serum leptin concentrations in women with polycystic ovary syndrome

The Journal of Clinical Endocrinology and Metabolism
J RouruM Koulu

Abstract

The role of gonadotropins, androgens, and insulin in the regulation of circulating leptin levels is obscure. In order to clarify the relationships of these parameters we studied serum leptin levels in 19 healthy control subjects and in 35 hyperandrogenic and hyperinsulinemic patients with polycystic ovary syndrome (PCOS). Serum leptin concentrations did not differ significantly between PCOS patients and control subjects. When PCOS and control groups were analyzed together by univariate analysis, serum leptin was positively correlated with body mass index (BMI), body weight, serum insulin, serum triglyceride, and serum free testosterone concentrations. Serum leptin was inversely correlated with serum sex hormone binding globulin (SHBG) concentrations. There were no significant correlations between serum leptin and testosterone, androstenedione, or gonadotropin concentrations. Serum insulin, triglyceride, and free testosterone concentrations were positively correlated, and serum SHBG was negatively correlated with BMI. However, when BMI on one hand and serum insulin, triglyceride, free testosterone, or SHBG on other hand were used as independent variables in the partial correlation analysis with leptin, BMI turned out to be the v...Continue Reading

References

Jul 28, 1995·Science·M A PelleymounterF Collins
Sep 28, 1995·The New England Journal of Medicine·S Franks
May 28, 1993·Annals of the New York Academy of Sciences·A Dunaif
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jun 1, 1996·Diabetes·S M HaffnerR L Gingerich
Aug 29, 1996·The New England Journal of Medicine·R D Utiger
Jul 1, 1996·Endocrinology·I A BarashR A Steiner
Nov 1, 1996·Diabetes·J F CaroR V Considine

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Citations

Dec 14, 2004·Journal of Assisted Reproduction and Genetics·Hisham Ali SalehEbtehag Mohamed Eldaqaq
Mar 4, 1998·Proceedings of the National Academy of Sciences of the United States of America·J LicinioP W Gold
Apr 17, 2010·Mediators of Inflammation·Thozhukat Sathyapalan, Stephen L Atkin
Jul 21, 2011·Journal of Nutrition and Metabolism·Betty N Wu, Anthony J O'Sullivan
Oct 10, 1998·Journal of Endocrinological Investigation·M P Leondires, S L Berga
Aug 2, 2012·Cellular and Molecular Life Sciences : CMLS·Carol F Elias, Darshana Purohit
Dec 22, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D MacutA Campana
Dec 22, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B BaranowskaA Płonowski
Aug 11, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Bożena Bidzińska-SpeichertAndrzej Milewicz
Apr 3, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Blagovest Pehlivanov, Mitko Mitkov
Nov 17, 2009·Reproductive Biomedicine Online·Gabriella GarrutiFrancesco Giorgino
Jul 1, 2015·International Journal of Endocrinology·Dinka Pavicic BaldaniRoya Ougouag
Apr 27, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H C MendonçaR A Ferriani
Sep 7, 2017·Reproductive Sciences·Romualdi DanielaLanzone Antonio
Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
Oct 23, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S JahanfarM Jahanfar
May 29, 2004·Journal of Physiology and Biochemistry·P A Martínez-CarpioA Corominas
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S SöderbergB Ahrén
Apr 18, 2003·Endocrine Reviews·Fredrick C W Wu, Arnold von Eckardstein
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J F Caro
Feb 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·P FedorcsákT Abyholm
Jul 26, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Somaye AhmadiMehdi Hedayati
Mar 11, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C Di CarloC Nappi
Mar 20, 1999·The Journal of Clinical Endocrinology and Metabolism·S K AgarwalD A Magoffin
Sep 13, 2007·The Journal of Clinical Endocrinology and Metabolism·Rupal ShroffAnuja Dokras
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Francesco OrioGaetano Lombardi
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·C KarlssonB Carlsson
Aug 3, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D K PanidisE Koumantakis
May 29, 2016·Diabetes/metabolism Research and Reviews·Lina Saleh HassanKirstie K Danielson
Nov 26, 1999·Obesity Research·S Wu-PengR L Leibel
May 20, 2000·Annals of the New York Academy of Sciences·C S Mantzoros
Oct 22, 2008·The Journal of Obstetrics and Gynaecology Research·Aysun BideciPeyami Cinaz
Jul 15, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C T ErelE Tasan
May 30, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jukka T KeroIlpo T Huhtaniemi
Oct 24, 1998·Clinical Physiology·G FrühbeckA M Prentice

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