PMID: 9635165Jun 23, 1998Paper

Serum leptin levels and energy expenditure in normal weight women

Canadian Journal of Physiology and Pharmacology
L J MartinJ F Caro

Abstract

To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin ...Continue Reading

Citations

Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Berna Binnur KivircikSena Yeşil
Apr 3, 2001·European Journal of Clinical Investigation·A Glasow, S R Bornstein
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A W Thorburn, J Proietto
Apr 14, 2000·Journal of the American College of Nutrition·M S BuchowskiE A Turner
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·A W ThorburnJ Proietto
May 11, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Verena K HaasManfred J Müller

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