Serum leptin levels in the acquired immunodeficiency syndrome

The Journal of Clinical Endocrinology and Metabolism
Carl GrunfeldK R Feingold

Abstract

Leptin, a hormone that is secreted by adipose tissue in proportion to fat stores, regulates energy balance and appetite. Recently, tumor necrosis factor and interleukin-1, cytokines that regulate the host response to infection, have been shown to acutely increase leptin levels, raising the possibility that leptin could mediate the anorexia of some infections. We measured leptin levels in patients with the acquired immunodeficiency syndrome and found that leptin levels were not increased relative to body fat in patients who were anorectic, were losing weight, or had a history of weight loss. Furthermore, leptin levels were not increased during secondary infection, suggesting that elevations in leptin do not play a key role in the anorexia of infections associated with acquired immunodeficiency syndrome.

Citations

May 15, 2007·Mediators of Inflammation·Hakan BuyukoglanMustafa Ozesmi
Oct 18, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa A KosmiskiCarl Grunfeld
Sep 25, 2012·Journal of Clinical Laboratory Analysis·Daniel A de LuisJose M Eiros Bouza
Jun 25, 1999·Metabolism: Clinical and Experimental·H J AndersM Schattenkirchner
Dec 2, 1999·Heart & Lung : the Journal of Critical Care·T A Lennie
Feb 25, 2009·Annals of the New York Academy of Sciences·Anna Carla GoldbergLuiz Vicente Rizzo
Apr 25, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·V PapaevangelouM Theodoridou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.