PMID: 344160Mar 1, 1978Paper

Serum level of immunoreactive gastrin: influence of kidney function

Gut
R HällgrenG Lundqvist

Abstract

Serum gastrin levels have been studied in 70 patients with chronically reduced glomerular filtration rate (GFR) as estimated by 51Cr-EDTA clearance, creatinine, and beta2-microglobulin values. A strong dependence upon GFR was found, although the correlation between gastrin levels and GFR was not as high as that between beta2-microglobulin and GFR, indicating the existence of extrarenal factors regulating the levels of circulating gastrin. In a separate group of 31 patients on maintenance dialysis the mean gastrin level was 65.9 pmol/l--that is, a fourfold increase compared to healthy subjects. Three of the uraemic patients had pronounced rises in serum gastrin in the range 800-1800 pmol/l. Finally, the influence of acute alterations of kidney function on serum gastrin was studied in 11 patients undergoing renal transplantation. In addition to a GFR dependence the results indicate the existence of feedback mechanisms in gastrin homeostasis. Although the clinical importance of the increased gastrin levels in renal failure is unknown, hypergastrinaemia occurs with sufficient frequency to be involved in upper gastrointestinal complications of uraemic patients.

References

Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Lundqvist, L Wide
Jan 1, 1975·The American Journal of Medicine·T Maack
Jan 1, 1973·Nephron·L WibellI Berggård
Feb 2, 1974·Lancet·R King, J Hansky
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jan 22, 1972·British Medical Journal·M G KormanJ Hansky
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Jun 1, 1973·Archives of Surgery·R A BoothJ C Thompson

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Citations

Feb 1, 1993·Digestive Diseases and Sciences·J Y Kang
Aug 31, 1979·World Journal of Surgery·J Hansky
Oct 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Stridsberg, G Lundqvist
May 1, 1979·Clinical Endocrinology·G LundqvistR Hällgren
Dec 1, 1980·Gut·I L TaylorG J Dockray
Nov 5, 2011·Gut·John K RamageUNKNOWN UK and Ireland Neuroendocrine Tumour Society
Aug 30, 2013·Canadian Journal of Physiology and Pharmacology·Shoukri A WakimRadwa H Ali
Jan 1, 1979·Scandinavian Journal of Gastroenterology·O CrivelliG Verme
Sep 1, 1983·The American Journal of Medicine·J M Boyle, B Johnston
Jan 1, 1986·The American Journal of Medicine·E SpindelJ E McGuigan
Dec 30, 2015·Critical Reviews in Food Science and Nutrition·David C DallasJ Bruce German
Feb 15, 2007·The British Journal of Nutrition·R RashidS F Ahmed
Jun 1, 1984·Journal of Endocrinological Investigation·A PezzarossaU Butturini
Oct 23, 2008·Annals of Clinical Biochemistry·Joy E S Ardill

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