Serum level of long noncoding RNA H19 as a diagnostic biomarker of multiple myeloma

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yafang PanHui Cong

Abstract

Circulating long noncoding RNA (lncRNA) H19 has been reported to be a biomarker for cancer monitoring. The purpose of this study was to determine whether serum lncRNA could serve as a novel biomarker for the diagnosis of multiple myeloma (MM) and evaluate its value of clinical application. In our study, the expression of lncRNA H19 was up-regulated in 80 patients with MM and MM cell lines by RT-PCR analysis. Clinicopathological analysis showed the expression level of H19 could assist clinical staging, and the severity of the disease could be roughly determined according to the amount of H19 expressed in the patient serum. This is the first report to show that H19 was expressed in the serum of MM patients, suggesting that upregulation of serum lncRNA H19 may prove to be a novel biomarker for early diagnosis and clinical treatment of MM.

Citations

Aug 26, 2018·Hematological Oncology·Lenka SedlarikovaSabina Sevcikova
Feb 15, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Wei ZongRongrong Jing
Oct 30, 2018·Journal of Cellular Physiology·Qian YangShaoqing Ju
Apr 21, 2019·International Journal of Molecular Sciences·Mila Gugnoni, Alessia Ciarrocchi
Feb 6, 2020·Cancers·Eugenio MorelliNicola Amodio
Apr 24, 2020·Journal of Cellular Physiology·Jingwen LiYu Hu
Aug 24, 2018·International Journal of Molecular Sciences·Mette DahlKirsten Grønbæk
Oct 22, 2019·Frontiers in Oncology·Mercedes BermúdezRosalío Ramos-Payán
May 15, 2020·Reproductive Biology and Endocrinology : RB&E·Xi XiaAmanda Kallen
Feb 20, 2019·International Journal of Molecular Sciences·Chiara CorradoRiccardo Alessandro
Jan 27, 2019·Non-coding RNA·Romana ButovaRoman Hajek
Oct 28, 2019·Experimental Hematology·Qingqing YinShaoqing Ju
Dec 19, 2020·Scientific Reports·Tamina Elias-RizkGeorge Hilal
May 1, 2021·Cancers·Arantxa Carrasco-LeónXabier Agirre

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