Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis

Human Cell
Hisamitsu IdeShigeo Horie

Abstract

Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.

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Citations

Jul 1, 2011·Medical Oncology·Maria KowalskaJan Walewski
Aug 6, 2010·Multivariate Behavioral Research·Seth M SpainFritz Drasgow
Dec 18, 2013·International Journal of Biological Sciences·Shalini ChaturvediShobha Seetharam
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arkadiusz Z DudekUNKNOWN Cancer and Leukemia Group B
Oct 31, 2012·Cancer Treatment Reviews·Stéphane Oudard
Mar 22, 2012·Medicinal Research Reviews·Mohammed I El-GamalChang-Hyun Oh
Dec 14, 2011·Clinical & Developmental Immunology·Marc BaayFilip Lardon
Apr 22, 2014·The Tohoku Journal of Experimental Medicine·Yong XuXu Zhang
Jul 16, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne-Laure ChénéChristophe Blanquart
Jan 25, 2018·Immunology and Cell Biology·Rong WangGuoguang Zheng
Mar 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudine NeyenThorsten Hagemann
Aug 28, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen A AutioHeather L McArthur

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