Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes

PloS One
Alan C H LeeKathryn C B Tan

Abstract

The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of diabetic complications, and soluble forms of the receptor (sRAGE) can counteract the detrimental action of the full-length receptor by acting as decoy. Soluble RAGE is produced by alternative splicing [endogenous secretory RAGE (esRAGE)] and/or by proteolytic cleavage of the membrane-bound receptor. We have investigated the role of A Disintegrin And Metalloproteinase 10 (ADAM10) in the ectodomain shedding of RAGE. Constitutive and insulin-induced shedding of RAGE in THP-1 macrophages by ADAM10 was evaluated using an ADAM10-specific metalloproteinase inhibitor. Serum ADAM10 level was measured in type 1 diabetes and control subjects, and the association with serum soluble RAGE was determined. Serum total sRAGE and esRAGE were assayed by ELISA and the difference between total sRAGE and esRAGE gave an estimated measure of soluble RAGE formed by cleavage (cRAGE). RAGE shedding (constitutive and insulin-induced) was significantly reduced after inhibition of ADAM10 in macrophages, and insulin stimulated ADAM10 expression and activity. Diabetic subjects have higher serum total sRAGE and esRAGE (p<0.01) than controls, and serum ADAM10 was also inc...Continue Reading

References

Jun 14, 2005·Trends in Biochemical Sciences·Ari-Pekka J HuovilaRebekka M Ortiz
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Thomas TousseynDieter Hartmann
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ci-Di ChenCarmela R Abraham
Dec 20, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Barry I HudsonAnn Marie Schmidt
Mar 22, 2008·Biochemical and Biophysical Research Communications·Arnaud GalichetClaus W Heizmann
Jul 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela RaucciMarco E Bianchi
Oct 28, 2008·Seminars in Cell & Developmental Biology·Jessica Pruessmeyer, Andreas Ludwig
Mar 12, 2009·Clinical Science·Anastasia Z KaleaBarry I Hudson
Sep 4, 2009·Internal and Emergency Medicine·Natale VazzanaGiovanni Davì
Jan 5, 2011·European Journal of Cell Biology·Paul Saftig, Karina Reiss
Apr 5, 2011·Clinical Science·Drazenka Pongrac BarlovicKarin A M Jandeleit-Dahm
May 25, 2011·Current Alzheimer Research·Kristina Endres, Falk Fahrenholz
Sep 3, 2011·Journal of Neurochemistry·Rolf Postina
Nov 30, 2011·Journal of Neurochemistry·Valérie Vingtdeux, Philippe Marambaud
Dec 6, 2011·European Journal of Cell Biology·Daniela DreymuellerAndreas Ludwig
Jan 4, 2012·Annals of the New York Academy of Sciences·Ravichandran RamasamyAnn Marie Schmidt
Aug 4, 2012·PloS One·Verena V MetzRolf Postina
Feb 26, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·J K Y LamK C B Tan
Aug 24, 2013·Journal of Lipid Research·Patricia Quade-LyssyElzbieta Kojro

❮ Previous
Next ❯

Citations

Nov 20, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Akio MiyoshiHidenori Koyama
Jul 20, 2017·European Journal of Clinical Investigation·Ting-Wei LeeYi-Jen Chen
Sep 6, 2019·Oxidative Medicine and Cellular Longevity·Nurbubu T MoldogazievaAlexander A Terentiev
Feb 13, 2021·Cellular and Molecular Life Sciences : CMLS·Tatsuo KawaiSatoru Eguchi
Aug 8, 2021·International Journal of Molecular Sciences·Marlena TypiakAgnieszka Piwkowska

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
ELISA

Software Mentioned

cRAGE

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.