Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes.

PloS One
Bruce A PerkinsPaul J Thornalley

Abstract

To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed "early GFR decline") in patients with type 1 diabetes. From the 1(st) Joslin Kidney Study, we selected 30 patients with longstanding normoalbuminuria and 55 patients with new onset microalbuminuria. Patients with microalbuminuria had 8-12 years follow-up during which 33 had stable GFR and 22 early GFR decline. Mean baseline GFR(CYSTATIN C) was similar between the three groups. Glycation, oxidation and nitration markers were measured in protein and ultrafiltrate at baseline by liquid chromatography-tandem mass spectrometry using the most reliable methods currently available. Though none were significantly different between patients with microalbuminuria with stable or early GFR decline, levels of 6 protein damage adduct residues of plasma protein and 4 related free adducts of plasma ultrafiltrate were significantly different in patients with microalbuminuria compared to normoalbuminuria controls. Three protein damage adduct residues were decreased and 3 increased in microalbuminuria while 3 free adducts were decreased and one increased in microalbumi...Continue Reading

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Citations

Feb 14, 2013·Heart Failure Reviews·Vijaya Lakshmi BodigaSreedhar Bodiga
Jul 6, 2014·Psychiatry and Clinical Neurosciences·Makoto AraiMasanari Itokawa
Oct 9, 2019·Life Science Alliance·Manabu ToyoshimaNobutaka Hirokawa
Jan 19, 2016·Scientific Reports·Maya TanaseLaura Santambrogio
Jul 14, 2016·Glycoconjugate Journal·Naila RabbaniPaul J Thornalley
Jun 11, 2020·Nutrients·Attila BiróJudit Remenyik
Mar 5, 2021·Diabetologia·Bruce A PerkinsDavid Z I Cherney
Jan 29, 2014·Journal of the American Society for Mass Spectrometry·Andrea F Lopez-ClavijoPeter B O'Connor
Jul 25, 2021·International Journal of Environmental Research and Public Health·Juan SalazarValmore Bermúdez
Apr 3, 2014·Journal of Agricultural and Food Chemistry·Xi ShaoShengmin Sang

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