PMID: 3769978Aug 1, 1986Paper

Serum levels of ampicillin and gentamycin in neonates of varying gestational age

European Journal of Pediatrics
L B DahlG Størvold

Abstract

Serum concentrations of gentamycin and ampicillin were investigated at loading and in steady state in two groups of neonates, of 26-33 weeks and 34-40 weeks gestation. At loading the usual intravenous dose of gentamycin (2.5 mg/kg) was increased by 50%, the usual intravenous dose of ampicillin (50 mg/kg) by 100%. Gentamycin and ampicillin were administered subsequently at the same intervals, 12 h in the 34-40 weeks group, and 18 h in the 26-33 weeks group. Adequate serum levels were achieved from the first day of treatment. For practical reasons ampicillin and gentamycin can be administered subsequently at identical intervals also when the intervals exceed 12 h. The ideal dosing interval for gentamycin in very preterm neonates is 24 h. When treating small preterm and term neonates with an aminoglycoside, rapid serum concentration analyses should be available, and the treatment modified accordingly.

References

Jun 1, 1979·Archives of Disease in Childhood·S J AbramovichA Stewart
Nov 1, 1977·Archives of Disease in Childhood·B M AssaelF Sereni
Dec 1, 1971·The Journal of Infectious Diseases·G H McCrackenM L Thomas
Dec 1, 1971·The Journal of Infectious Diseases·J O KleinD Ingall
Aug 1, 1984·American Journal of Diseases of Children·S BuckwaldE A Egan
Jul 1, 1983·The Journal of Pediatrics·A M ArbeterS J Yaffe
Jan 1, 1981·Reviews of Infectious Diseases·H C Neu
Feb 1, 1982·Archives of Disease in Childhood·H Feldman, J P Guignard
Apr 1, 1981·Antimicrobial Agents and Chemotherapy·R M RatcliffR White

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Citations

Feb 3, 1999·Journal of Paediatrics and Child Health·M W Davies, D W Cartwright
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Anouk E MullerJohn N van den Anker
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·J J Huisman-de BoerR de Groot
Feb 11, 2005·Seminars in Fetal & Neonatal Medicine·Matthijs de HoogJohn N van den Anker
Apr 30, 1998·The Annals of Pharmacotherapy·C L ShafferP Gal
May 29, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Ghanshyam AgarwalRosita S Pildes
Oct 1, 1996·Therapeutic Drug Monitoring·B T IsemannC J Johnson
Aug 17, 2004·Scandinavian Journal of Infectious Diseases·Claus KlingenbergTrond Flaegstad
Oct 23, 2020·American Journal of Perinatology·Sin Yin Lim, Jamie L Miller

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