Serum levels of chemokines IP-10, IL-8 and SDF-1 serve as good biomarkers for diabetes-tuberculosis nexus

Journal of Diabetes and Its Complications
Vivekanandhan AravindhanV Viswanathan

Abstract

Inflammation has long been identified as an essential component of both Type-2 diabetes and tuberculosis. Chemokines are low molecular weight proteins which play an important role in both inflammation (diabetes) and immunity (tuberculosis). In this study, we measured the serum levels of IP-10, IL-8 and SDF-1 in subjects with Normal Glucose Tolerance (NGT-TB- = 108; NGT-TB+ = 200), Pre-Diabetes (PDM-TB- = 118; PDM-TB+ = 105), Newly Diagnosed Diabetes (NDM-TB- = 105; NDM-TB+ = 63) and Known Diabetes (KDM-TB- = 131; KDM-TB+ = 108), by ELISA. Along with chemokines pro-inflammatory cytokines TNF-ɑ and IL-6 were also measured in these groups. While IP-10 levels were significantly reduced in TB+ subjects in all the sub-groups, IL-8 levels were significantly reduced in NDM-TB+ and increased in KDM-TB+ subjects. SDF-1 levels were significantly elevated in TB+ subjects in all the subgroups, except for KDM-TB+. Altered serum chemokine levels can alter anti-TB immunity in diabetes patients and can fuel DM-TB nexus.

Citations

Aug 20, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yun ZhuFuqiang Hu
Jun 1, 2021·Frontiers in Immunology·Xiongfeng PanAizhong Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.