Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: proteomic analysis

Journal of Neuroimmunology
Setsu SawaiFumio Nomura

Abstract

To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

References

Mar 20, 2002·Current Neurology and Neuroscience Reports·I SteinerI Wirguin
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T KanesakaS Kuwabara
Jan 27, 2006·Annals of Neurology·David N IraniAvindra Nath
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanUNKNOWN AFFIRM Investigators
Mar 3, 2006·The New England Journal of Medicine·Richard A RudickUNKNOWN SENTINEL Investigators
Apr 12, 2006·Archives of Neurology·Sean J PittockMoses Rodriguez
Sep 15, 2006·The New England Journal of Medicine·Ludwig KapposUNKNOWN FTY720 D2201 Study Group
Sep 29, 2006·Annals of Neurology·Piero Del BoccioAndrea Urbani
Aug 29, 2007·Carcinogenesis·Radoslav GoldmanFrancoise Seillier Moiseiwitsch
Sep 21, 2007·Annals of Neurology·Nathalie KoningInge Huitinga
Aug 16, 2008·Lancet Neurology·Diego FranciottaFrancesca Aloisi
Mar 10, 2010·Human Molecular Genetics·Paola G BronsonLisa F Barcellos

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Citations

Sep 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiaki YanoFumio Nomura
Dec 4, 2012·International Journal of Molecular Sciences·Rocco SavinoRosa Terracciano
May 1, 2011·Expert Opinion on Medical Diagnostics·John W Rose, Noel G Carlson
Dec 7, 2013·Nucleic Acids Research·Vishalakshi NanjappaT S Keshava Prasad
Apr 6, 2011·Journal of the Neurological Sciences·Jerome J Graber, Suhayl Dhib-Jalbut
Oct 12, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stefanie KuertenPaul V Lehmann
Aug 17, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroshi UmemuraFumio Nomura
Jan 30, 2014·Journal of Immunological Methods·Katrine PilelyYaseelan Palarasah
Apr 23, 2010·Journal of Neuroimmunology·Gillian IngramB Paul Morgan
May 31, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sachio TsuchidaFumio Nomura
Feb 11, 2012·Journal of Proteome Research·Therese RosenlingTheo M Luider

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