PMID: 7546824Jan 1, 1995Paper

Serum levels of cytokines and soluble cytokine receptors in patients with metastatic renal cell carcinoma or malignant melanoma receiving IL-2/interferon-alpha combination therapy

Acta Oncologica
S D FossåH Gallati

Abstract

Elevated serum levels of soluble tumour necrosis factor receptor (sTNFR-55) and (at a lesser degree) of sTNFR-75 were found in most of the patients with metastatic renal cell carcinoma (RCC) or malignant melanoma (MM) before immunotherapy and with further increase during treatment (intravenous infusions of interleukin-2 [IL-2] and subcutaneous interferon-alpha [IFN-alpha]). In the majority of the patients with MM the pretreatment serum levels of IL-2 and soluble IL-2 receptor (sIL-2R) were increased, whereas fewer patients with RCC presented with increased serum levels of IL-2 and sIL-2R. Twelve days' treatment with IL-2/IFN-alpha, with a rest on days 6 and 7, resulted in a consistent further increase in the serum levels of sIL-2R and sTNFRs. In most patients the increase of sIL-2R and sTNFRs lasted for at least 3 weeks after treatment discontinuation. The clinical significance of the increase remains unknown.

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Citations

Nov 11, 1999·British Journal of Haematology·G J LockerO F Wagner
Oct 31, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gary BrewerSidney Pestka
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Patrizia PellegriniDomenico Adorno
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Anna Maria BerghellaDomenico Adorno
Dec 23, 2004·Clinical Neuropharmacology·Patrizia PellegriniDomenico Adorno
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S V KotenkoS Pestka
Jul 17, 1999·Critical Reviews in Clinical Laboratory Sciences·R Fernandez-Botran

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