Sep 15, 1977

Serum levels of d-norgestrel, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone in women during and following ingestion of combination oral contraceptives containing dl-norgestrel

American Journal of Obstetrics and Gynecology
P F BrennerU Goebelsmann


Three formulations of dl-norgestrel were administered daily to groups of three women for five consecutive days. The serum levels of d-norgestrel were related to the dosage of dl-norgestrel ingested. Peak concentrations in the circulation of synthetic gestagen were attained a half hour to three hours after oral administration, followed by a rapid and sharp decline in levels until the next dose. Three women received 500 micrograms of dl-norgestrel and 50 micrograms of ethinyl estradiol for 21 days followed by six to seven days of no medication for two consecutive cycles. The gonadotropins remained suppressed for four to six days when therapy was discontinued. The daily concentrations of estradiol varied from less than 5 to 81 pg. per milliliter, and there was no difference in estrogen values during the nontreatment and treatment days. Due to the long half life of norgestrel, the one-week pill-free interval is not long enough for the complete recovery of the reproductive axis from the inhibition of oral contraceptives.

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Mentioned in this Paper

Recombinant Gonadotropin
Depression, Chemical
Progesterone, (9 beta,10 alpha)-Isomer
Contraceptives, Oral
Estradiol, (16 alpha,17 beta)-Isomer
Ethinyl Estradiol
Hypothalamo-Hypophyseal System
Estradiol Measurement

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