PMID: 9438919Jan 24, 1998Paper

Serum levels of GH, IGF-I, LH and ovarian steroids in cyclic and RU486-treated rats

Journal of Endocrinological Investigation
A RuizJosé Eugenio Sánchez-Criado

Abstract

Rats lacking progesterone action due to RU486 treatment have been reported to show numerous endocrine and morphological similarities with respect to human polycystic ovary syndrome (PCO). Nevertheless, abnormalities on insulin or insulin-like growth factor I (IGF-I) production, a frequent finding in the polycystic disease, have not been studied in such rats yet. The aim of these experiments was to evaluate the serum concentrations of IGF-I in rats treated with 4 mg of the antiprogestagen RU486 over 4 or 8 consecutive days starting on estrus (day 1) and decapitated on the morning of day 5 and 9. Serum levels of growth hormone (GH), luteinizing hormone (LH), testosterone (T) and 17 beta estradiol (E2) were determined and correlated with those of IGF-I. Controls were rats injected with oil and killed in the morning of metestrus, diestrus, proestrus and estrus. Rats treated with RU486 had increased serum concentrations of IGF-I, LH, T and E2 with respect to control rats on estrus, while no differences were found in the serum concentrations of GH. Parallel estrous cycle related changes were observed in the serum concentrations of IGF-I, T and E2 with the highest values at proestrus. However, changes on serum concentrations of GH wer...Continue Reading

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Citations

Mar 17, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M SzczukoE Stachowska
Feb 18, 2012·Biology of Reproduction·Kirsty A WaltersDavid J Handelsman
Aug 23, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Hong ZhouShinichi Ohno
Nov 29, 2005·Human Reproduction·Kalpana LakhaniPaul Hardiman
Apr 17, 2002·Maturitas·R Druckmann, U D Rohr

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