PMID: 8603021Feb 1, 1996Paper

Serum levels of GM-CSF are elevated in patients with thrombocytopenia

British Journal of Haematology
M R AbboudJ Bussel

Abstract

Serum levels of GM-CSF, IL-3 and IL-6 were measured in patients with immune thrombocytopenia (ITP), non-immune thrombocytopenia (NIT), autoimmune haemolytic anaemia (AIHA) and neutropenia. 8/10 children with ITP had elevated serum levels of GM-CSF (mean 18.4 pg/ml) while thrombocytopenic, but only two had detectable levels (mean 4.5 pg/ml) after normalization of the platelet count. In patients with NIT a significant inverse correlation between platelet count and serum levels of GM-CSF was observed. IL-3 and IL-6 levels were not significantly elevated in thrombocytopenic patients and only two of the nine patients with either AIHA or neutropenia had detectable levels of GM-CSF. Thus, GM-CSF may play a role in the response of severe thrombocytopenia.

Citations

Oct 1, 2009·La Revue de médecine interne·Bernard Bonnotte
Apr 29, 2006·British Journal of Haematology·Nichola Cooper, James Bussel
Mar 14, 2002·American Journal of Hematology·J W SempleUNKNOWN Canadian Children's Platelet Study Group
Dec 12, 2003·Journal of Pediatric Hematology/oncology·John W Semple
Mar 3, 1998·Journal of Pediatric Hematology/oncology·W L FurmanW H Meyer
Sep 11, 2018·Journal of Neuroimmunology·Milos KosticIvana Stojanovic
Sep 30, 2006·Transfusion Medicine Reviews·Alan T TinmouthDonald R Branch

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