Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Changwoo HanDai-Jin Kim

Abstract

This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, bu...Continue Reading

References

Oct 1, 1991·British Journal of Addiction·E HartkaK M Fillmore
Jul 1, 1985·Acta Psychiatrica Scandinavica·A L von KnorringL Oreland
Mar 1, 1995·The American Journal of Psychiatry·J R CorneliusJ J Mann
May 1, 1994·The American Journal of Psychiatry·T I MuellerH Akiskal
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Sep 30, 2000·Brain Research. Brain Research Reviews·G J Siegel, N B Chauhan
Apr 3, 2002·Psychiatry Research·Félicien KaregeJean-Michel Aubry
Jan 19, 2005·Molecular Psychiatry·F AngelucciA A Mathé
Aug 13, 2005·Biological Psychiatry·Lisa M HinesUNKNOWN WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence Investigators
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Patricia H JanakDorit Ron
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Su-Jung YoonDai-Jin Kim
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Keun-Ho JoeDai-Jin Kim
Jan 25, 2008·Alcoholism, Clinical and Experimental Research·Lorenzo LeggioGiovanni Addolorato
Aug 5, 2008·Trends in Neurosciences·Carmine M Pariante, Stafford L Lightman
Jun 24, 2009·Human Psychopharmacology·Wakako Umene-NakanoJun Nakamura
Aug 19, 2011·Alcoholism, Clinical and Experimental Research·Marie-Agnès CostaDominique Malauzat
Apr 11, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Breno S DinizOrestes V Forlenza

❮ Previous
Next ❯

Citations

Aug 21, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jung Min Jo, Sung Doo Won

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection
Assay
ELISA

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.