Serum levels of IGF-1 are related to human skin characteristics including the conspicuousness of facial pores

International Journal of Cosmetic Science
Yoriko Sugiyama-NakagiriTakashi Kitahara

Abstract

Conspicuous facial pores are one type of serious aesthetic defects for many women. However, the mechanism(s) that underlie the conspicuousness of facial pores remains unclear. We previously characterized the epidermal architecture around facial pores that correlates with the appearance of those pores in various ethnic groups including Japanese. The goal of this study was to evaluate the possible relationships between facial pore size, the severity of impairment of epidermal architecture around facial pores and sebum output levels to investigate the possible role of IGF-1 in the pathogenesis of conspicuous facial pores. The subjects consisted of 38 healthy Japanese women (aged 22-41 years). IGF-1 was measured using immunoradiometric assay. Surface replicas were collected to compare pore sizes of cheek skin and horizontal cross-section images of cheek skin were obtained non-invasively from the same subjects using in vivo confocal laser scanning microscopy and the severity of impairment of epidermal architecture around facial pores was determined. The skin surface lipids of each subject were collected from their cheeks and lipid classes were determined using gas chromatography/flame ionization detection. The serum level of IGF-1 c...Continue Reading

References

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Feb 6, 2008·Journal of Dermatological Science·Yoriko Sugiyama-NakagiriTakashi Kitahara
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Nov 8, 2008·Journal of Dermatological Science·Yoriko Sugiyama-NakagiriTakashi Kitahara

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Citations

Jun 23, 2010·Archives of Dermatological Research·Yoriko Sugiyama-NakagiriTakashi Kitahara
Feb 27, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sang Ju LeeSeong Jun Seo
Apr 8, 2019·International Journal of Cosmetic Science·R SchützD Imfeld
Aug 20, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Seongwoo LeeSun Gyoo Park

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