Serum levels of IL-17 are elevated in patients with acute gouty arthritis

Biochemical and Biophysical Research Communications
Yang LiuYongtong Cao

Abstract

Acute gouty arthritis (AGA) is one of the most common forms of auto-inflammatory arthritis. IL-17 is a key proinflammatory cytokine which has been implicated in several autoimmune diseases. However, to date little is known about the role of IL-17 in AGA. In the present study, we show that serum IL-17 levels are significantly elevated in AGA patients early in the onset of symptoms of gout, and decrease gradually as symptoms diminish. Correlation analysis indicated that IL-17 expression is not only positively correlated with disease activity, but is also correlated with serum levels of IL-1β which plays a critical role in the differentiation of IL-17-γδT cells into IL-17+γδT cells. Flow cytometry analysis indicated that γδ T cells are a major source of IL-17 production during the early onset of AGA. We therefore identify IL-17 as a potential novel biomarker for AGA and suggest that targeting the γδ T cell/IL-17 immune axis is a potential strategy for treatment of acute flares of AGA.

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Citations

Nov 7, 2018·International Journal of Rheumatic Diseases·Isela Montúfar-RoblesJulián Ramírez-Bello
Oct 15, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·S C-S HuH-P Tu
Nov 20, 2019·Journal of Clinical Medicine·Veronika HorváthováBlanka Stibůrková
Jan 12, 2020·Bioorganic & Medicinal Chemistry Letters·Weiwei WangQinghua Hu

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