Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment

PloS One
Malgorzata Gorska-CiebiadaJerzy Loba

Abstract

The aim of the study was to determine the serum levels of CRP, IL-6 and TNF-α in elderly diabetic patients with depressive syndrome alone or with coexisting mild cognitive impairment (MCI). 276 diabetics elders were screened for depressive symptoms (using Geriatric Depression Scale: GDS-30) and MCI (using the Montreal Cognitive Assessment: MoCA score). Data of HbA1c, blood lipids and inflammatory markers levels were collected. In all groups of patients levels of CRP, IL-6 and TNF-α were significantly higher as compared to controls. The highest level of inflammatory markers was detected in group with depressive mood and coexisting MCI, however IL-6 level didn't significantly differ as compared to MCI group. We founded correlations between all inflammatory markers in group of patients with depressive mood and in group of subjects with depressive symptoms and coexisting MCI. GDS-30 score was correlated with levels of inflammatory markers in group with depressive mood, and with levels of CRP and TNF-α in group with depressive mood and coexisting MCI. In the group with depressive mood and coexisting MCI we founded that MoCA score was negatively correlated with CRP and TNF-α levels; and HbA1c level was positively correlated with all ...Continue Reading

References

Jan 1, 1970·The Gerontologist·S KatzR C Grotz
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Aug 4, 2001·Psychosomatic Medicine·M de GrootP J Lustman
May 24, 2003·Psychosomatic Medicine·Marion DannerViola Vaccarino
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Apr 7, 2004·Archives of General Psychiatry·Henning TiemeierMonique M B Breteler
Jun 9, 2004·Journal of Affective Disorders·Vincent CamusGérard Waeber
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Aug 9, 2005·American Heart Journal·Amy K FerketichPhilip F Binkley
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Mar 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·F PortetUNKNOWN MCI Working Group of the European Consortium on Alzheimer's Disease (EADC)
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert E IosifOlle Lindvall
Dec 13, 2006·Biological Psychiatry·George S Alexopoulos
Apr 11, 2007·Archives of Neurology·José A LuchsingerRichard Mayeux
May 29, 2007·The American Journal of Cardiology·Mohammed F FaramawiUNKNOWN Cardiovascular Health Study Investigators
Jul 3, 2007·Brain, Behavior, and Immunity·Ning Quan, William A Banks
Aug 21, 2007·Neurochemical Research·Brian E Leonard
Sep 19, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ahmed A ArifJane Colmer-Hamood
Jan 6, 2009·Current Opinion in Psychiatry·Timothy G Dinan
Feb 4, 2009·Psychosomatic Medicine·M Bryant HowrenJerry Suls
Jul 2, 2009·Alzheimer Disease and Associated Disorders·Rosebud O RobertsRonald C Petersen
Sep 16, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rosebud O RobertsRonald C Petersen
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Francesco PanzaVincenzo Solfrizzi
Aug 17, 2010·Diabetologia·A NouwenUNKNOWN European Depression in Diabetes (EDID) Research Consortium
Aug 28, 2010·Diabetes·Jie DingUNKNOWN Edinburgh Type 2 Diabetes Study Investigators
Jan 22, 2011·Dementia and Geriatric Cognitive Disorders·Julian N TrollorPerminder Sachdev
Oct 25, 2011·Neuroscience and Biobehavioral Reviews·Michael J Stuart, Bernhard T Baune
Dec 14, 2011·Dementia and Geriatric Cognitive Disorders Extra·Hiroyuki UmegakiTakahisa Sano

❮ Previous
Next ❯

Citations

Nov 29, 2015·Aging Clinical and Experimental Research·Malgorzata Gorska-CiebiadaJerzy Loba
Oct 4, 2015·Metabolic Brain Disease·Malgorzata Gorska-CiebiadaJerzy Loba
Mar 16, 2017·Journal of the American Medical Directors Association·Abebaw M YohannesMartin J Connolly
Apr 8, 2017·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Malgorzata Gorska-Ciebiada, Maciej Ciebiada
Sep 1, 2018·Annals of the American Thoracic Society·Samuel M BrownRamona O Hopkins
Sep 1, 2016·Irish Journal of Psychological Medicine·C DolanB Lawlor
Apr 24, 2018·Current Diabetes Reviews·Salwa S HosnyGhada A Hasanin
Dec 5, 2019·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Rong FanWei-Wei Ma
Apr 30, 2020·EMBO Molecular Medicine·Lien D Nguyen, Barbara E Ehrlich
Feb 8, 2019·Current Medicinal Chemistry·Jiyin ZhouGuisheng Qian
Jun 24, 2017·International Journal of Geriatric Psychiatry·Andrew P KeeganMichael Mullan
Feb 15, 2019·Frontiers in Endocrinology·Anup BhusalKyoungho Suk
Nov 3, 2016·Journal of Clinical Psychopharmacology·Avin MuthuramalingamVir Singh Negi
Dec 20, 2018·International Journal of Molecular Sciences·Cini Mathew JohnFazlin Mohd Fauzi
Jan 18, 2021·Experimental Gerontology·Joanna RymaszewskaDorota Szcześniak
May 1, 2021·International Journal of Molecular Sciences·Iwona Piatkowska-ChmielJaroslaw Dudka
Jun 1, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Hadeel A Al-RawafAhmad H Alghadir

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
ELISA

Software Mentioned

Statistica

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.