Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein-1 and -3 in women with regular menstrual cycles

Fertility and Sterility
H S WangY K Soong

Abstract

To investigate the cyclic changes of serum insulin-like growth factor (IGF-I), IGF-binding protein-1 (IGFBP-1) and IGFBP-3 levels during ovulatory menstrual cycle. A prospective study following a preset protocol. A tertiary-care academic medical center. Thirty young female adults with regular menstrual cycles were recruited (18 with normal luteal phase and 12 with inadequate luteal function confirmed by serum P levels). Serum concentrations of IGF-I, IGFBP-1, and IGFBP-3 from women with regular menstrual cycles were assayed. Circulating E2 and P levels also were determined to certify the ovulatory cycles. In women with normal luteal function, there was a peak of serum IGFBP-1 levels before ovulation concomitant with the preovulatory E2 peak. The nadir of serum IGFBP-1 levels was in the midluteal phase. Circulating IGFBP-1 elevated rapidly during late luteal phase and reached a peak on the 1st day of menstruation then declined slightly until a preovulatory IGFBP-1 peak occurred. In women with inadequate luteal function (midluteal serum levels of P < 10 ng/mL [conversion factor to SI unit, 3.180]), the preovulatory increase in serum IGFBP-1 was not significant and the circulating IGFBP-1 levels fluctuated throughout the menstrual...Continue Reading

Citations

Oct 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H S Wang, Y K Soong
Aug 12, 2003·Breast Cancer Research and Treatment·Charlotta Dabrosin
Nov 17, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A LukanovaR Kaaks
Oct 6, 2004·Expert Opinion on Investigational Drugs·Maria B GrantRobert N Mames
May 16, 2000·Critical Reviews in Clinical Laboratory Sciences·R E Banks
Apr 13, 2002·Annals of the New York Academy of Sciences·Bruce A Lessey
Nov 15, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H S WangY K Soong
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura BagliettoGraham G Giles
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul

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