Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis

Journal of the American College of Cardiology
Mototsugu NishiiTohru Izumi

Abstract

We assessed the significance of serum cytokine levels in patients with fulminant myocarditis. Although many investigations have demonstrated the crucial role of cytokines in the development of myocarditis, it remains uncertain whether serum levels of cytokines enable one to predict the prognosis of human myocarditis, especially concerning cardiogenic shock (CS) requiring a mechanical cardiopulmonary support system (MCSS). We studied 22 consecutive patients with fulminant myocarditis and compared them with 15 patients with acute myocardial infarction (AMI) requiring MCSS. The patients with myocarditis were classified into three groups: eight patients with CS requiring MCSS on admission (group 1); six patients who unexpectedly lapsed into CS requiring MCSS more than two days after catecholamine had been initiated (group 2); and eight patients without MCSS (group 3). Furthermore, 14 patients with myocarditis requiring MCSS were divided into a fatal group (n = 5) and a survival group (n = 9). Biochemical markers, including serum cytokine levels and hemodynamic variables on admission, were analyzed. Serum levels of interleukin (IL)-10 and tumor necrosis factor-alpha, but not other cytokines, were significantly higher in myocarditis ...Continue Reading

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Citations

Oct 16, 2012·Heart and Vessels·Tadaaki AbeOsamu Yamada
Apr 10, 2009·The New England Journal of Medicine·Leslie T Cooper
Jun 19, 2007·Cardiology in Review·Christopher R Ellis, Thomas Di Salvo
Nov 30, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Mototsugu NishiiToru Izumi
Apr 12, 2014·Current Heart Failure Reports·Bernhard MaischSabine Pankuweit
Mar 1, 2009·Expert Opinion on Medical Diagnostics·Irene Meester, Juan Manuel Solis-Soto
Dec 22, 2011·Lancet·Sandeep SagarLeslie T Cooper
Oct 9, 2012·International Journal of Cardiology·Sang Hee LeeJun-Hyok Oh
Oct 5, 2013·Inflammation·Célio Gomes de AmorimMaria José Carvalho Carmona
Feb 22, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marilia SeelaenderFilippo Rossi-Fanelli
Jan 5, 2005·Journal of the American College of Cardiology·Anthony N DemariaSotirios Tsimikas
Jan 24, 2014·Expert Review of Cardiovascular Therapy·Fredy R S GutierrezJoão S Silva
Jun 13, 2017·Clinical & Experimental Neuroimmunology·Ikuo TsunodaAh-Mee Park
Dec 12, 2020·Signal Transduction and Targeted Therapy·Weijian HangDao Wen Wang
Jan 30, 2008·Journal of Cardiac Failure·Ayman A El-Menyar
Jan 30, 2010·Progress in Cardiovascular Diseases·Lori A Blauwet, Leslie T Cooper

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