Serum levels of interleukin-15 and interleukin-10 and their correlation with proliferating cell nuclear antigen in multiple myeloma

Cytokine
C PappaMichael G Alexandrakis

Abstract

In order to determine prognostic factors characterizing multiple myeloma (MM) cell kinetics, bone marrow proliferative activity and serum Interleukin-10 (IL-10), and Interleukin-15 (IL-15) levels were measured in 40 newly diagnosed MM patients, compared with 10-age and sex-matched-healthy controls. Cell proliferation was evaluated by employing a monoclonal antibody directed against the proliferating cell nuclear antigen (PCNA), whereas IL-10 and IL-15 were measured with quantitative sandwich enzyme immunoassay methods. IL-15, IL-10 and PCNA were higher in the patient group than in controls (P<0.001). IL-10 levels, and PCNA increased significantly with increasing Durie-Salmon disease stage (I-III, P<0.002, and P=0.001, respectively). Serum IL-15 levels in MM stage III patients were elevated in comparison with stages I and II, the difference however, did not reach statistical significance. There was a significant positive correlation between serum IL-15 and IL-10 levels (r: 0.372, P<0.01), and between serum IL-10 and PCNA (r: 0.608, P<0.0001), as well as a positive correlation of serum IL-15 with PCNA, which marginally failed to reach statistical significance. Serum IL-15 levels are elevated in MM patients, increase with advancin...Continue Reading

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Citations

Jan 22, 2013·Annals of Hematology·Elif SuyanıRauf Haznedar
Mar 4, 2011·European Journal of Human Genetics : EJHG·Herbert PangStéphane Minvielle
Sep 29, 2011·Journal of Translational Medicine·Chantal MengusStephen Wyler
Feb 18, 2016·British Journal of Cancer·Hua WangYue Lu
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Aug 13, 2013·BioMed Research International·Michael G AlexandrakisGeorge Tsirakis
Jul 25, 2012·Oncology Reports·Pedro L Martínez-HernándezJoaquín Sánchez García-Girón
Apr 4, 2021·International Journal of Molecular Sciences·Dominika BębnowskaPaulina Niedźwiedzka-Rystwej
Aug 14, 2021·Tzu Chi Medical Journal·Cheng-Der LiuWei-Han Huang

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