Serum levels of interleukin-2 predict the recurrence of atrial fibrillation after pulmonary vein ablation

Cytokine
Fernando Cabrera-BuenoJavier Alzueta

Abstract

Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exists between inflammation and the outcome of catheter ablation of AF. We studied 44 patients with paroxysmal AF who underwent catheter ablation. Patients with structural heart disease, coronary artery or valve disease, active inflammatory disease, known or suspected neoplasm, endocrinopathies, or exposure to anti-inflammatory drugs were excluded. All study participants underwent evaluation with a standardized protocol, including echocardiography, and cytokine levels of interleukin-2, interleukin-4, interleukin-6, interleukin-10, tumour necrosis factor-alpha, and gamma-interferon determination before procedure. Clinical and electrocardiographic follow-up were performed with Holter-ECG at 3, 6 and 12months in order to know if sinus rhythm was maintained. After catheter ablation of the 44 patients included (53±10years, 27.3% female), all patients returned to sinus rhythm. During the first year of follow-up seven patients (15...Continue Reading

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Citations

Mar 19, 2016·The American Journal of Cardiology·Kadri Murat GursesKudret Aytemir
Jul 9, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hui JiangYinglong Hou
Jun 24, 2017·Pacing and Clinical Electrophysiology : PACE·Peng ChenLiang Xia
Jul 28, 2020·Circulation Research·Na Li, Bianca J J M Brundel
Mar 23, 2017·BMC Infectious Diseases·Héctor Rodríguez-AnguloManuel Fresno
Aug 15, 2020·Frontiers in Cardiovascular Medicine·Gabriela Lopes MartinsHelton José Reis
Oct 1, 2020·BMC Cardiovascular Disorders·Pascal B MeyreSven Knecht
Mar 6, 2021·Journal of Arrhythmia·Nso NsoFarshid Radparvar

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