Abstract
In order to clarify the clinical significance of serum interleukin 4 (IL-4) levels, we measured serum IL-4 concentrations in allergic and non-allergic children using a highly sensitive sandwich ELISA. The limit of detection of the assay was 0.15 pg/ml in serum samples. Serum IL-4 was detected in 96.3% (53/55) of non-allergic controls, in 92.9% (183/197) of allergic children, in 70% (7/10) of cord blood samples and in 86.7% (26/30) of neonates. The IL-4 levels in sera from non-allergic controls were relatively constant during the ages examined and all samples were under 1.5 pg/ml. In allergic children, the serum levels of IL-4 were significantly elevated, particularly at age 13-24 months. The serum levels of IL-4 did not differ in children with different clinical manifestations of allergy, such as bronchial asthma, and atopic dermatitis. The serum level of soluble CD23 (sCD23) showed an age-dependent change in allergic and non-allergic children and was significantly higher in allergic than in non-allergic infants aged 7 to 12 months, but not in other age groups. There was no significant correlation among serum levels of IL-4, sCD23 and IgE. It is suggested that the measurement of serum IL-4 and sCD23 is helpful in the examinatio...Continue Reading
References
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HsiehK M Murphy
Nov 1, 1992·The Journal of Experimental Medicine·P BraddingC H Heusser
Sep 1, 1992·The Journal of Allergy and Clinical Immunology·K JujoD Y Leung
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jul 11, 1992·The American Review of Respiratory Disease·C WalkerJ C Virchow
Jan 1, 1991·The Journal of Allergy and Clinical Immunology·F RoussetJ E de Vries
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Delespesse, M Sarfati
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P ParronchiS Romagnani
Aug 1, 1991·Clinical and Experimental Immunology·T MatsumotoJ Yodoi
Mar 1, 1991·The Journal of Experimental Medicine·A B KayQ Hamid
Sep 1, 1990·The Journal of Experimental Medicine·G Le GrosW E Paul
Jul 1, 1989·Pediatric Research·K M KimH Mikawa
Jan 1, 1989·Advances in Immunology·T R Mosmann, R L Coffman
Jan 1, 1988·European Journal of Immunology·J Y BonnefoyJ Banchereau
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Jul 1, 1988·Immunological Investigations·G DelespesseH Frost
Jan 28, 1994·Cell·W E Paul, R A Seder
Mar 1, 1994·Chest·K MatsumotoK Takagi
Apr 1, 1993·Clinical and Experimental Immunology·M TangG Varigos
Citations
Jun 1, 1996·European Journal of Pediatrics·M HatzistilianouF Athanassiadou
Sep 29, 2001·Allergy·A DaschnerM Martín-Esteban
Apr 24, 1999·The British Journal of Dermatology·M FurueN Yamashita
Aug 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Jul 25, 2000·Archives of Disease in Childhood·A Sahid El-RadhiC J Corrigan
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·N KrugH Fabel
Oct 8, 1998·American Journal of Respiratory Cell and Molecular Biology·G R DuboisP L Bruijnzeel
Jan 17, 2012·Immunology·Anne Månsson Kvarnhammar, Lars Olaf Cardell
Sep 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·H OttR Fölster-Holst
Jul 5, 2005·Expert Opinion on Investigational Drugs·M Hingorani
Jul 23, 2016·Mediators of Inflammation·S F WangS H He
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Charity NofzigerMarkus Paulmichl
Jun 24, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M P Borres, B Björkstén
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stuart L GoldsteinDouglas M Silverstein
May 7, 2020·British Journal of Pharmacology·Amy M Chinn, Paul A Insel
Sep 4, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Karen KnippingJohan Garssen
Aug 5, 2011·Clinical Pharmacology and Therapeutics·C NofzigerM Paulmichl
Mar 10, 2009·Allergologia et immunopathologia·A CuéllarE García