Serum levels of interleukin 4 and soluble CD23 in children with allergic disorders

European Journal of Pediatrics
Y OhshimaM Mayumi

Abstract

In order to clarify the clinical significance of serum interleukin 4 (IL-4) levels, we measured serum IL-4 concentrations in allergic and non-allergic children using a highly sensitive sandwich ELISA. The limit of detection of the assay was 0.15 pg/ml in serum samples. Serum IL-4 was detected in 96.3% (53/55) of non-allergic controls, in 92.9% (183/197) of allergic children, in 70% (7/10) of cord blood samples and in 86.7% (26/30) of neonates. The IL-4 levels in sera from non-allergic controls were relatively constant during the ages examined and all samples were under 1.5 pg/ml. In allergic children, the serum levels of IL-4 were significantly elevated, particularly at age 13-24 months. The serum levels of IL-4 did not differ in children with different clinical manifestations of allergy, such as bronchial asthma, and atopic dermatitis. The serum level of soluble CD23 (sCD23) showed an age-dependent change in allergic and non-allergic children and was significantly higher in allergic than in non-allergic infants aged 7 to 12 months, but not in other age groups. There was no significant correlation among serum levels of IL-4, sCD23 and IgE. It is suggested that the measurement of serum IL-4 and sCD23 is helpful in the examinatio...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HsiehK M Murphy
Nov 1, 1992·The Journal of Experimental Medicine·P BraddingC H Heusser
Sep 1, 1992·The Journal of Allergy and Clinical Immunology·K JujoD Y Leung
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Delespesse, M Sarfati
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P ParronchiS Romagnani
Aug 1, 1991·Clinical and Experimental Immunology·T MatsumotoJ Yodoi
Jan 1, 1989·Advances in Immunology·T R Mosmann, R L Coffman
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Jul 1, 1988·Immunological Investigations·G DelespesseH Frost
Jan 28, 1994·Cell·W E Paul, R A Seder
Apr 1, 1993·Clinical and Experimental Immunology·M TangG Varigos

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Citations

Jun 1, 1996·European Journal of Pediatrics·M HatzistilianouF Athanassiadou
Aug 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Jul 25, 2000·Archives of Disease in Childhood·A Sahid El-RadhiC J Corrigan
Jan 17, 2012·Immunology·Anne Månsson Kvarnhammar, Lars Olaf Cardell
Sep 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·H OttR Fölster-Holst
Jul 5, 2005·Expert Opinion on Investigational Drugs·M Hingorani
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Charity NofzigerMarkus Paulmichl
Jun 24, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M P Borres, B Björkstén
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stuart L GoldsteinDouglas M Silverstein
Sep 4, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Karen KnippingJohan Garssen
Aug 5, 2011·Clinical Pharmacology and Therapeutics·C NofzigerM Paulmichl

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