Serum levels of irisin predict short-term outcomes in ischemic stroke

Cytokine
Huisheng WuJianjuan Ke

Abstract

Irisin is a 112-amino acid peptide found in rat and human skeletal muscle after exercise. Previous studies had suggested that higher circulating irisin levels were associated with an increased risk of vascular atherosclerosis and cardiovascular diseases. In this study, we determined irisin levels in serum, and investigated their associations with functional outcomes in a 3-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). From September 2015 to December 2016, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum irisin levels were measured at admission. Functional impairment was evaluated at discharge using the modified Rankin scale. The levels of irisin were expressed as median and interquartile ranges [IQR]. The irisin level was obtained in 324 patients (97.6%) with a median value of 291.2 ng/ml (IQR: 214.1-404.2 ng/ml). There were significantly negative correlations between levels of irisin and NHISS (r = -0.272; P < 0.001) and BMI (r = -0.193; P = 0.003). A poor functional outcome was found in 99 patients (30.6%; 95%CI: 25.5-35.6%). The poor functional outcome distribution across the irisin quartiles ranged between 51.9% (first...Continue Reading

Citations

Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Oct 3, 2020·International Journal of Molecular Sciences·Kyeongho Byun, Sewon Lee
Jan 4, 2021·Molecular Biology Reports·Jun Ma, Ken Chen
Mar 31, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Helong QuanZsolt Radak
Feb 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Graziana ColaianniMaria Grano
May 1, 2021·International Journal of Molecular Sciences·Lidia WlodarczykElzbieta Miller

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