Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis.

Gastroenterology
Jasmohan S BajajPatrick M Gillevet

Abstract

Inpatients with cirrhosis have high rates of acute-on-chronic failure (ACLF) development and high mortality within 30 days of admission to the hospital. Better biomarkers are needed to predict these outcomes. We performed metabolomic analyses of serum samples from patients with cirrhosis at multiple centers to determine whether metabolite profiles might identify patients at high risk for ACLF and death. We performed metabolomic analyses, using liquid chromatography, of serum samples collected at time of admission to 12 North American tertiary hepatology centers from 602 patients in the North American Consortium for the Study of End-Stage Liver Disease sites from 2015 through 2017 (mean age, 56 years; 61% men; mean model for end-stage liver disease score, 19.5). We performed analysis of covariance, adjusted for model for end-stage liver disease at time of hospital admission, serum levels of albumin and sodium, and white blood cell count, to identify metabolites that differed between patients who did vs did not develop ACLF and patients who did vs did not die during hospitalization and within 30 days. We performed random forest analysis to identify specific metabolite(s) that were associated with outcomes and area under the curve...Continue Reading

References

Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray KimHashem El-Serag
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel A Langer, Vijay H Shah
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Apr 15, 2008·Molecular Microbiology·Pratik Shah, Edwin Swiatlo
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
May 22, 2010·Chemistry & Biodiversity·Ammar NaqviPatrick Gillevet
Sep 21, 2010·BMC Gastroenterology·Horace R T WilliamsTimothy R Orchard
Jun 21, 2011·Trends in Microbiology·Elaine HolmesJeremy K Nicholson
Apr 25, 2012·Metabolic Brain Disease·Jasmohan S BajajSimon D Taylor-Robinson
Jul 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajUNKNOWN NACSELD
Jul 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jasmohan S BajajPatrick M Gillevet
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Jan 1, 2014·Journal of Hepatology·Jasmohan S BajajPatrick M Gillevet
Mar 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajUNKNOWN North American Consortium For The Study Of End-Stage Liver Disease (NACSELD)
Feb 26, 2015·Journal of Gastroenterology and Hepatology·Yanfei ChenLanjuan Li
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Jason M Ridlon, Jasmohan S Bajaj
Jan 23, 2016·Journal of Hepatology·Mark J W McPhailSimon D Taylor-Robinson
Mar 5, 2016·Gut Microbes·Jason M RidlonPhillip B Hylemon
May 14, 2016·Seminars in Liver Disease·Vicente Arroyo, Rajiv Jalan
Aug 3, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joan ClàriaUNKNOWN CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (
Aug 26, 2016·Clinical and Translational Gastroenterology·Dae J KangJasmohan S Bajaj
Oct 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenPatrick S Kamath
Oct 5, 2016·JCI Insight·Ta-Chiang LiuNita H Salzman
Jan 6, 2017·Gut·Ruben HernaezPere Ginès
Apr 11, 2017·European Journal of Nutrition·Ian RowlandKieran Tuohy
Sep 20, 2017·Alcoholism, Clinical and Experimental Research·Jasmohan S BajajPatrick M Gillevet
Jan 10, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jacqueline G O'LearyJasmohan S Bajaj
Feb 23, 2018·Frontiers in Cellular and Infection Microbiology·Jing GaoYulong Yin
Mar 4, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jasmohan S BajajPatrick M Gillevet
Mar 9, 2018·JCI Insight·Jasmohan S BajajPatrick M Gillevet
Apr 25, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong
Jul 24, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jasmohan S BajajPatrick M Gillevet
Aug 19, 2018·Nature Communications·Henrik M Roager, Tine R Licht
Sep 22, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Celeste AllabandRob Knight
Sep 30, 2018·Journal of Hepatology·Sumeet K AsraniPatrick S Kamath
Dec 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joan ClàriaUNKNOWN CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and the European Foundation for the Study of Chronic
May 21, 2019·Bioscience of Microbiota, Food and Health·Yuji Ohashi, Tomohiko Fujisawa

❮ Previous
Next ❯

Citations

Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Jordan Hindson
Dec 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Jonel TrebickaManimozhiyan Arumugam
Oct 11, 2020·The American Journal of Gastroenterology·Chang HuJasmohan S Bajaj
Mar 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Meng YuZhong-Mei Zou
May 28, 2021·Journal of Hepatology·Richard MoreauPatrick S Kamath
May 28, 2021·Journal of Hepatology·Jonel TrebickaJasmohan S Bajaj
Jun 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ezequiel MauroAdrián Gadano
May 19, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong
Aug 17, 2021·Frontiers in Physiology·Tilman SauerbruchUlrich Beuers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Richard Moreau, Vicente Arroyo
Liver International : Official Journal of the International Association for the Study of the Liver
Francois DurandClaire Francoz
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Leah Maria KleinJonel Trebicka
© 2021 Meta ULC. All rights reserved